Evidence map›Paper›PMID 34765511›Full record

ArticleJournal of traditional and complementary medicine2021

Germán A Colareda, Soledad I Matera, Matías Bayley, María Inés Ragone, María Luján Flores, Osvaldo León Córdoba, Alicia E Consolini

Open access · diamondAbstract read
In one paragraph

Article in Journal of traditional and complementary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Efficacy and Safety of Maca (The world journal of men's health · 2023
    Article
  3. Article
  4. Article
  5. Use of Maca Powder (Veterinary sciences · 2022
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Germán A ColaredaCátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina.
Soledad I MateraCátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina.
Matías BayleyCátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina.
María Inés RagoneCátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina.
María Luján FloresCátedra de Farmacognosia, Grupo de Investigación en Química, Bioactividad y Metabolismo de Recursos Naturales Patagónicos, AAI, CRIDECIT, Facultad de Ciencias Naturales y Ciencias de la Salud, Universidad Nacional de la Patagonia San Juan Bosco, Km 4, s/N°, Comodoro Rivadavia, 9000, Chubut, Argentina.
Osvaldo León CórdobaCátedra de Química Biológica II, Grupo de Investigación en Química, Bioactividad y Metabolismo de Recursos Naturales Patagónicos, AAI, CRIDECIT, Facultad de Ciencias Naturales y Ciencias de la Salud, Universidad Nacional de la Patagonia San Juan Bosco, Km 4, s/N°, Comodoro Rivadavia, 9000, Chubut, Argentina.
Alicia E ConsoliniCátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina.
Universidad Nacional de La Plata · ARNational University of Patagonia San Juan Bosco · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimPhytoestrogens are traditionally used for cardiovascular risks but direct effects on the ischemic heart remain unclear. Plants with phytoestrogens are used for reducing menopausic symptoms and they could also be cardioprotectives. Here we investigated whether maca EXPERIMENTAL PROCEDURE: Both products were orally and daily administered to rats during 1 week before exposing isolated hearts to ischemia/reperfusion (I/R). Young male (YM), female (YF) and aged female (AgF) rats treated with maca (MACA, 1 g/kg/day) or soy isoflavones (ISOF, 100 mg/kg/day) were compared to acute daidzein (DAZ, 5 mg/kg i.p.) and non-treated rat groups. Isolated ventricles were perfused inside a calorimeter to simultaneously measure contractile and calorimetrical signals before and during I/R. RESULTS AND

conclusionsMaca has genistein and daidzein. MACA and ISOF improved the post-ischemic contractile recovery (PICR) and muscle economy (P/Ht) in YM and YF hearts, but not in AgF hearts. DAZ improved PICR and P/Ht more in YM than in YF. The mK

Indexed as

5-HD, 5-hydroxydecanoateAgF, aged female ratsCalciumCardiomyocytesCICUAL, Institutional Committee for Care of Laboratory AnimalsCONICET, National Council of Scientific and Technical ResearchDaidzeinDAZ, daidzeinDMSO, dimethylsulphoxideF, Fisher coefficient for variance statistical testHPLC, high performance liquid chromatographyHt, total heat ratei.p, intraperitonealI/R, ischemia and reperfusionIsoflavonesISOF, soy isoflavonesl-NAME, Nω-nitro-l-arginine methyl ester hydrochlorideMacaMACA, Lepidium meyenii root powderMitochondriamKATP channelsmKATP, mitochondrial ATP-dependent K+ channelsmNCXmNCX, mitochondrial Na/Ca exchangerMyocardial economyNOSNOS, nitric oxide synthasesP/Ht, muscle economyPICR, post-ischemic contractile recoveryPKC, protein-kinase CP, maximal pressure developed in contractionROS, reactive oxygen speciesSEM, standard error of mediaTFT, triphenyltetrazolium chlorideYF, young female ratsYM, young maleΔLVEDP, resting diastolic pressure

Identifiers

PMID34765511
PMCPMC8572714
OpenAlexW3144491837

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.