ArticleTranslational pediatrics2021
Age- and sex-specific reference intervals for thyroid hormones in a Chinese pediatrics: a prospective observational study of 1,279 healthy children.
Article in Translational pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Establishment of Reference Intervals for Plasma TSH Across the Lifespan in an Algerian Mediterranean Population.Journal of clinical laboratory analysis · 2026Article
- Latent Symptom Profiles in Adolescents With Major Depressive Disorder: Subjective Sleep Disturbance and Biopsychosocial Correlates.Depression and anxiety · 2026Article
- Prediction of thyroid function based on CT radiomics: a two-center study.Quantitative imaging in medicine and surgery · 2025Article
- Association of micronutrient status with thyroid function in adolescent Afghan refugees; a cross-sectional study.Thyroid research · 2025Article
- Age- and sex-specific reference intervals for anti-Müllerian hormone during childhood in Chinese population: a cross-sectional study of 2,450 healthy children.Translational pediatrics · 2025Article
- Age- and sex-specific reference intervals for sex hormones in children in Wuhan: a cross-sectional study of 2,477 healthy children and adolescents.Translational pediatrics · 2025Article
- Neonatal Thyroid-Stimulating Hormone Reference Intervals in Multi-Ethnics Population.Children (Basel, Switzerland) · 2025Article
- MCT8 Deficiency in Two Brothers With a Novel Deletion Mutation inCase reports in genetics · 2025Article
- A Prospective Cohort Study on the Effect of Antiseizure Medications on Thyroid Function in Children Aged 6 Months to 12 Years with Epilepsy.Sultan Qaboos University medical journal · 2024Article
- Psychotic symptoms in Chinese adolescent patients with major depressive disorder: prevalence and related endocrine clinical factors.BMC psychiatry · 2024Article
- Specific reference interval for high-sensitivity cardiac troponin I among healthy children in Wuhan, China.Translational pediatrics · 2024Article
- The role of vitamin D in slipped capital femoral epiphysis in children and adolescents: a retrospective case-control study.Frontiers in endocrinology · 2024Article
- Distribution of serum uric acid concentration and its association with lipid profiles: a single-center retrospective study in children aged 3 to 12 years with adenoid and tonsillar hypertrophy.Lipids in health and disease · 2023Article
- Possible Association Between Thyroid Nodule Formation and Developmental Alterations in the Pituitary-Thyroid Hormone Axis in Children and Adolescents: The Fukushima Health Management Survey.Thyroid : official journal of the American Thyroid Association · 2022Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThyroid hormones are essential for early neurocognitive development and growth and development in childhood and adolescence. However, the reference intervals (RIs) for thyroid hormones in Chinese pediatric individuals remain unclear. This study aimed to establish thyroid hormone RIs for a Chinese pediatric population according to appropriate age- and sex-specific partitioning.
methodsIn this prospective observational study, a total of 1,279 healthy children (singletons, aged from 1 day to 12 years) were recruited, and serum samples were analyzed on a Mindray automated chemiluminescence immunoassay analyzer CL-6000i for thyroid hormone detection, including thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), total triiodothyronine (T3), and total thyroxine (T4). Age and sex-specific RIs were established, and the corresponding 95% confidence intervals (CIs) were calculated in accordance with the Clinical Laboratory Standards Institute (CLSI) document C28-A3 guidelines.
resultsQuantile testing revealed that the median (P50) and RIs [2.5
conclusionsPediatric RIs of thyroid hormones display age- and sex-specific trends. The RIs established in this study will improve the accuracy of TSH assay result interpretations and clinical decision-making in clinical laboratories that utilize the Mindray analytical platform.
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