ArticleTranslational pediatrics2021
The effects of early rehabilitation in high-risk infants with brain injury: a systematic review and meta-analysis.
Article in Translational pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Strategies for addressing the needs of children with or at risk of developmental disabilities in early childhood by 2030: a systematic umbrella review.BMC medicine · 2024Pooled it
- Longitudinal Analysis of Growth and Neurodevelopmental Outcomes in Very Low Birth Weight Infants With Congenital Anomalies Over Three Years.Journal of Korean medical science · 2025Article
- Development and Validation of an MRI-Based Brain Volumetry Model Predicting Poor Psychomotor Outcomes in Preterm Neonates.Journal of clinical medicine · 2025Article
- Preservation of Bilateral Corticospinal Projections from Injured Hemisphere After Perinatal Stroke.Brain sciences · 2025Article
- The Long-Term Outcome and Rehabilitative Approach of Intraventricular Hemorrhage at Preterm Birth.Journal of Korean Neurosurgical Society · 2023Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA meta-analysis was conducted to examine the effects of early rehabilitation on the incidence of sequelae and associated disabilities in high-risk infants with brain injury.
methodsEnglish and Chinese medical databases including PubMed, Web of Science and Embase, China National Knowledge Infrastructure (CNKI) and Wanfang database, were search from 2005 to 2020 for relevant studies related to rehabilitation in high-risk children with brain injury. Patients who received basic treatment combined with early rehabilitation after brain injury formed the treatment group, and infants who only received basic treatment were considered the control group. The data were statistically analyzed using Stata16.0 analysis software.
resultsA total of 13 studies were included, involving 1,930 patients. Meta-analysis showed that the effective rate of early rehabilitation in the treatment of high-risk children with brain injury was significantly higher than that of the control group without early rehabilitation [odds ratio (OR) =4.98; 95% confidence interval (CI): 3.66 to 6.79]. Early rehabilitation also significantly improved patient adaptability [standardized mean difference (SMD) =0.632; 95% CI: 0.496 to 0.769], gross motor skills (SMD =0.971; 95% CI: 0.705 to 1.236), fine motor skills (SMD =0.904; 95% CI: 0.670 to 1.138), language skills (SMD =0.757; 95% CI: 0.483 to 1.030), and personal-social scores (SMD =0.786; 95% CI: 0.648 to 0.925) compared to patients in the control group. The mental development index (MDI) score (SMD =1.194; 95% CI: 0.839 to 1.549) and the psychomotor development index (PDI) score (SMD =0.973; 95% CI: 0.661 to 1.286) were significantly higher in the treatment group compared to the control group. DISCUSSION: Early rehabilitation therapy can improve the neuromotor and intellectual development in high-risk infants with brain injury.
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