Evidence map›Paper›PMID 34765284›Full record

ArticleACS catalysis2019

A High-Throughput Method for Directed Evolution of NAD(P)

Rui Huang, Hui Chen, David M Upp, Jared C Lewis, Yi-Heng P Job Zhang

Open access · greenAbstract read
In one paragraph

Article in ACS catalysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
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  8. EngineeringACS catalysis · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Cell-Free Noncanonical Redox Cofactor Systems.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  14. Article
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  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Rui HuangBiological Systems Engineering Department, Virginia Tech, Blacksburg, Virginia 24061, United States.ORCID 0000-0001-6424-3659
Hui ChenBiological Systems Engineering Department, Virginia Tech, Blacksburg, Virginia 24061, United States.ORCID 0000-0002-8944-0090
David M UppDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
Jared C LewisDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.ORCID 0000-0003-2800-8330
Yi-Heng P Job ZhangTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West 7th Avenue, Tianjin Airport Economic Area, Tianjin 300308, China.ORCID 0000-0002-4010-2250
Indiana University Bloomington · USVirginia Tech · USChinese Academy of Sciences · CN

Funding

Directed Evolution of Halogenases For Small Molecule FunctionalizationR01GM115665 · NIGMS · UNIVERSITY OF CHICAGO · PI LEWIS, JARED C · 2015 to 2022
$2.5M
NIGMS NIH HHS R01 GM115665
6 · The paper itself

Abstract

Engineering flavin-free NAD(P)

Indexed as

biomimetic nicotinamide analoguescoenzyme regenerationdirected evolutionhigh-throughput screeningNAD(P)+-dependent dehydrogenases

Identifiers

PMID34765284
PMCPMC8580058
OpenAlexW2985852251

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.