Evidence map›Paper›PMID 34765280›Full record

ArticleJournal of pharmaceutical analysis2021

Simulation of the oxidative metabolization pattern of netupitant, an NK

Ruxandra Chira, Jens Fangmeyer, Ioan O Neaga, Valentin Zaharia, Uwe Karst, Ede Bodoki, Radu Oprean

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ruxandra ChiraAnalytical Chemistry Department, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400349, Cluj-Napoca, Romania.
Jens FangmeyerUniversity of Münster, Institute of Inorganic and Analytical Chemistry, 48149, Münster, Germany.
Ioan O NeagaAnalytical Chemistry Department, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400349, Cluj-Napoca, Romania.
Valentin ZahariaOrganic Chemistry Department, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400012, Cluj-Napoca, Romania.
Uwe KarstUniversity of Münster, Institute of Inorganic and Analytical Chemistry, 48149, Münster, Germany.
Ede BodokiAnalytical Chemistry Department, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400349, Cluj-Napoca, Romania.
Radu OpreanAnalytical Chemistry Department, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400349, Cluj-Napoca, Romania.
Iuliu Hațieganu University of Medicine and Pharmacy · ROUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering the frequent use of netupitant in polytherapy, the elucidation of its oxidative metabolization pattern is of major importance. However, there is a lack of published research on the redox behavior of this novel neurokinin-1 receptor antagonist. Therefore, this study was performed to simulate the intensive hepatic biotransformation of netupitant using an electrochemically driven method. Most of the known enzyme-mediated reactions occurring in the liver (i.e.,

Indexed as

EC/LC/MSNetupitantNeurokinin-1 antagonistOxidative metabolism

Identifiers

PMID34765280
PMCPMC8572700
OpenAlexW3140939248

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.