Evidence map›Paper›PMID 34765229›Full record

ArticleBMJ open sport & exercise medicine2021

Efficacy of high-volume injections with and without corticosteroid compared with sham for Achilles tendinopathy: a protocol for a randomised controlled trial.

Peter Malliaras, David Connell, Anders Ploug Boesen, Rebecca S Kearney, Hylton B Menz, Dylan Morrissey, Shannon E Munteanu, Karin G Silbernagel, Martin Underwood, Terry P Haines

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open sport & exercise medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 4 countries.

Peter MalliarasSchool of Primary and Allied Health Care, Monash University, Frankston, Victoria, Australia.ORCID 0000-0001-5879-4139
David ConnellSchool of Primary and Allied Health Care, Monash University, Frankston, Victoria, Australia.
Anders Ploug BoesenDepartment of Orthopaedic Surgery, Hvidovre Hospital, Copenhagen, Denmark.
Rebecca S KearneyWarwick Medical School, University of Warwick, Coventry, West Midlands, UK.
Hylton B MenzDiscipline of Podiatry, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Victoria, Australia.
Dylan MorrisseySports and Exercise Medicine, Queen Mary University of London, London, UK.
Shannon E MunteanuDiscipline of Podiatry, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Victoria, Australia.
Karin G SilbernagelDepartment of Physical Therapy, University of Delaware, Newark, DE, USA.
Martin UnderwoodWarwick Medical School, University of Warwick, Coventry, West Midlands, UK.
Terry P HainesSchool of Primary and Allied Health Care, Monash University, Frankston, Victoria, Australia.
La Trobe University · AUMonash University · AUHvidovre Hospital · DKOlympic Park Sports Medicine Centre · AUQueen Mary University of London · GBUniversity Hospitals Coventry and Warwickshire NHS Trust · GBUniversity of Delaware · USUniversity of Warwick · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAchilles tendinopathy (AT) is a common and disabling musculoskeletal condition. First-line management involving Achilles tendon loading exercise with, or without, other modalities may not resolve the problem in up to 44% of cases. Many people receive injections. Yet there are no injection treatments with demonstrated long-term efficacy. The aim of the trial is to examine the 12-month efficacy of high-volume injection (HVI) with corticosteroid and HVI without corticosteroid versus sham injection among individuals with AT. METHODS AND ANALYSIS: The trial is a three-arm, parallel group, double-blind, superiority randomised controlled trial that will assess the efficacy of HVI with and without corticosteroid versus sham up to 12 months. We will block-randomise 192 participants to one of the three groups with a 1:1:1 ratio, and both participants and outcome assessors will be blinded to treatment allocation. All participants will receive an identical evidence-based education and exercise intervention. The primary outcome measure will be the Victorian Institute of Sport Assessment - Achilles (VISA-A) at 12 months post-randomisation, a validated, reliable and disease-specific measure of pain and function. Choice of secondary outcomes was informed by core outcome domains for tendinopathy. Data will be analysed using the intention-to-treat principle. ETHICS AND DISSEMINATION: Ethics approval was obtained via the Monash University Human Ethics Committee (no: 13138). The study is expected to be completed in 2024 and disseminated via peer review publication and conference presentations. TRIAL REGISTRATION NUMBER: Australia and New Zealand Clinical trials registry (ACTRN12619001455156).

Indexed as

Achilles tendinopathyhigh volume injectioninjectionrandomised controlled trial

Identifiers

PMID34765229
PMCPMC8543648
OpenAlexW3210843121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.