Evidence map›Paper›PMID 34765108›Full record

ArticleHepatic oncology2022

Transarterial chemoembolization alone or followed by bevacizumab for treatment of colorectal liver metastases.

Giammaria Fiorentini, Donatella Sarti, Michele Nardella, Riccardo Inchingolo, Massimiliano Nestola, Alberto Rebonato, Caterina Fiorentini, Camillo Aliberti, Roberto Nani, Stefano Guadagni

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Hepatic oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03732235 (Observational Study on Transarterial Chemoembolization With Irinotecan-loaded Embolics Associated With Systemic Bevacizumab for the Treatment of Refractory Liver Metastases From Colorectal Cancer), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03732235 unknown statusnot on this map

Observational Study on Transarterial Chemoembolization With Irinotecan-loaded Embolics Associated With Systemic Bevacizumab for the Treatment of Refractory Liver Metastases From Colorectal Cancer

TypeobservationalSponsorGiammaria FiorentiniRan2018 to 2021Enrolled50ConditionsLiver Metastasis Colon CancerArmsTACE+ systemic Bevacizumab, FOLFIRI+Bevacizumab, TACE
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Giammaria FiorentiniDepartment of Oncology-Hematology, Azienda Ospedaliera Ospedali Riuniti Marche Nord, Pesaro, 61122, Italy.ORCID https://orcid.org/0000-0002-5615-889X
Donatella SartiDepartment of Oncology-Hematology, Azienda Ospedaliera Ospedali Riuniti Marche Nord, Pesaro, 61122, Italy.ORCID https://orcid.org/0000-0002-8031-7846
Michele NardellaDiagnostic & Interventional Radiology Department, Ospedale Madonna delle Grazie, Matera, 75100, Italy.ORCID https://orcid.org/0000-0002-1573-511X
Riccardo InchingoloDiagnostic & Interventional Radiology Department, Ospedale Madonna delle Grazie, Matera, 75100, Italy.ORCID https://orcid.org/0000-0002-0253-5936
Massimiliano NestolaDiagnostic & Interventional Radiology Department, Ospedale Madonna delle Grazie, Matera, 75100, Italy.ORCID https://orcid.org/0000-0001-9611-865X
Alberto RebonatoDiagnostics for Images Unit & Interventional Radiology, Azienda Ospedaliera Ospedali Riuniti Marche Nord, Pesaro, 61122, Italy.ORCID https://orcid.org/0000-0002-4075-2827
Caterina FiorentiniDepartment of Medical Biotechnologies, University of Siena, Siena, 53100, Italy.ORCID https://orcid.org/0000-0002-9346-1409
Camillo AlibertiDiagnostic & Interventional Radiology Department, Ospedale Pederzoli, Peschiera del Garda, 37019, Verona.ORCID https://orcid.org/0000-0002-0941-7457
Roberto NaniDepartmental Unit of Interventional Radiology, ASST Papa Giovanni XXIII, Bergamo, 24127, Italy.ORCID https://orcid.org/0000-0002-0923-5151
Stefano GuadagniDepartment of Applied Clinical Sciences & Biotechnology, Section of General Surgery, University of L'Aquila, L'Aquila, 67100, Italy.ORCID https://orcid.org/0000-0001-8525-084X
Ospedale Madonna Delle Grazie · ITOspedali Riuniti Marche Nord · ITCasa di Cura Villa Garda · ITOspedale Papa Giovanni XXIII · ITUniversity of L'Aquila · ITUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsBevacizumab (B) in association with systemic chemotherapy is commonly used for the treatment of colorectal cancer liver metastases. The aim of this study was to monitor tumor response, overall survival (OS) and progression-free survival (PFS) of patients with colorectal cancer liver metastases treated with transarterial chemoembolization (TACE) + B compared with TACE alone and to correlate the results with PATIENTS &

methodsThis was an observational multicentric case-control study (NCT03732235) on the efficacy and safety of B administered after TACE.

resultsThe disease control rate was significantly higher for the TACE + B than the TACE alone group (p < 0.001).

conclusionThe combination of TACE with B may improve tumor response and delay disease progression.

Indexed as

angiogenesisbevacizumabcolorectal carcinomaDC beads radiopaqueirinotecanliver metastasespolyethylene glycol microspherestransarterial chemoembolization

Identifiers

PMID34765108
PMCPMC8577510
OpenAlexW3177543750

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.