Evidence map›Paper›PMID 34765082›Full record

ArticleStatistics and its interface2019

Incorporating Deep Features in the Analysis of Tissue Microarray Images.

Donghui Yan, Timothy Randolph, Jian Zou, Peng Gong

Abstract read
In one paragraph

Article in Statistics and its interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Donghui YanDepartment of Mathematics, University of Massachusetts Dartmouth, MA 02747, USA.
Timothy RandolphFred Hutchinson Cancer Research Center, WA 98109, USA.
Jian ZouDepartment of Mathematical Sciences, Worcester Polytechnic Institute, MA 01609, USA.
Peng GongDepartment of ESPM, University of California Berkeley, CA 94720, USA; Department of Earth System Science, Tsinghua University, China.

Funding

Machine Learning Tools for Discovery and Analysis of Active Metabolic PathwaysR01GM114029 · NIGMS · UNIVERSITY OF WASHINGTON · PI SHOJAIE, ALI · 2016 to 2020
$1.7M
NIGMS NIH HHS R01 GM114029
6 · The paper itself

Abstract

Tissue microarray (TMA) images have been used increasingly often in cancer studies and the validation of biomarkers. TACOMA-a cutting-edge automatic scoring algorithm for TMA images-is comparable to pathologists in terms of accuracy and repeatability. Here we consider how this algorithm may be further improved. Inspired by the recent success of deep learning, we propose to incorporate representations learnable through computation. We explore representations of a group nature through unsupervised learning, e.g., hierarchical clustering and recursive space partition. Information carried by clustering or spatial partitioning may be more concrete than the labels when the data are heterogeneous, or could help when the labels are noisy. The use of such information could be viewed as regularization in model fitting. It is motivated by major challenges in TMA image scoring-heterogeneity and label noise, and the

Indexed as

automatic scoringhierarchical clusteringrecursive space partitioningTissue microarray images

Identifiers

PMID34765082
PMCPMC8579945

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.