Evidence map›Paper›PMID 34765025›Full record

ArticleExperimental and therapeutic medicine2021

Epigenetic regulation mechanism of DNA methylation and miRNAs on the expression of the

Xiaoshuai Bie, Huiling Zhao, Zhaojing Zhang, Xiaoou Wang, Yingying Luan, Yuanli Wang, Shangdong Yang, Liyan Xu, Xuran Zhang, Baixue Zhou and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Epigenetic Mechanisms in Heart Diseases.Reviews in cardiovascular medicine · 2025
    Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xiaoshuai BieDepartment of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Huiling ZhaoDepartment of Reproductive Genetics of Anyang Maternal and Child Health Care Hospital, Anyang, Henan 455000, P.R. China.
Zhaojing ZhangDepartment of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Xiaoou WangDepartment of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Yingying LuanDepartment of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Yuanli WangDepartment of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Shangdong YangDepartment of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Liyan XuHenan Eye Institute, Henan Eye Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China.
Xuran ZhangMedical Laboratory of The First Affiliated Hospital of Henan University of CM, Zhengzhou, Henan 450000, P.R. China.
Baixue ZhouDepartment of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Hui DongDepartment of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Yan XuDepartment of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Dongzhi YangSchool of Life Sciences of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Hong ZhengDepartment of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Ying HeDepartment of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5-lipoxygenase-activating protein (FLAP), encoded by the arachidonate 5-lipoxygenase-activating protein

Indexed as

arachidonate 5-lipoxygenase-activating proteinDNA methylationepigeneticsischemic strokemicroRNAs

Identifiers

PMID34765025
PMCPMC8576617

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.