ArticleEvidence-based complementary and alternative medicine : eCAM2021
The Preventive Value of Acupoint Sensitization for Patients with Stable Angina Pectoris: A Randomized, Double-Blind, Positive-Controlled, Multicentre Trial.
Article in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03975140 (The Preventive Value of Acupoint Sensitization Based on Stable Angina Pectoris), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Preventive Value of Acupoint Sensitization Based on Stable Angina Pectoris
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Acupoint Sensitivity in Health and Disease: A Systematic Review.Journal of integrative and complementary medicine · 2024Pooled it
- CHRNA3⁺ nociceptors prime the cutaneous sensory interface to enhance electroacupuncture analgesia.Chinese medicine · 2026Article
- Proteomics and Metabolomics-Based Investigation of Local Microenvironmental Changes in Sensitized Acupoint Compared to Non-Sensitized Point Among Patients with Chronic Atrophic Gastritis: A Cross-Sectional Study Protocol.Journal of pain research · 2026Article
- Plasma-derived exosomal miR-144-3p targeting IL-1β is involved in pressure pain threshold regulation at PC6 acupoint in myocardial ischemia rats.Journal of traditional and complementary medicine · 2026Article
- Article
- Acupuncture Dosage and Its Correlation with Effectiveness in Patients with Chronic Stable Angina: A Systematic Review and Meta-Analysis of Randomized Controlled Trial.Journal of pain research · 2025Review
- Acupuncture at Sensitized Acupoints versus Sham Acupuncture for Neck-Type Cervical Spondylosis: Study Protocol for a Randomized Controlled Trial.Journal of pain research · 2025Article
- The Impact and Correlation of Anxiety and Depression on Pressure Pain Threshold of Acupoints in Patients with Chronic Pelvic Inflammatory Disease.Pain research & management · 2023Article
- Sympathetic-Sensory Coupling as a Potential Mechanism for Acupoints Sensitization.Journal of pain research · 2023Review
- Knowledge mapping of acupoint sensitization and acupoint specificity: a bibliometric analysis.Frontiers in neuroscience · 2023Article
- Advancing the Understanding of Acupoint Sensitization and Plasticity Through Cutaneous C-Nociceptors.Frontiers in neuroscience · 2022Review
- Shared nociceptive dorsal root ganglion neurons participating in acupoint sensitization.Frontiers in molecular neuroscience · 2022Article
- Acupuncture Modulates the Spontaneous Activity and Functional Connectivity of Calcarine in Patients With Chronic Stable Angina Pectoris.Frontiers in molecular neuroscience · 2022Article
Corrections and comments
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Authors and funding
20 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcupoint sensitization is considered an important factor in the efficacy of acupoint therapy. This study aimed to evaluate the efficacy of acupressure in the prevention of stable angina pectoris using acupoints with different pressure-pain sensitivities.
methodsA total of 202 patients were enrolled and randomly assigned to a high-sensitivity group (HSG) (
resultsThe effect of acupressure compared with baseline on the prevention of angina pectoris in HSG was better than that in LSG at week 4 (incidence rate ratio (IRR): 0.691 and 95% confidence interval (CI): [0.569, 0.839]) and week 8 (IRR: 0.692 and 95% CI: [0.569, 0.839]). No significant difference between groups was found in the frequency of nitroglycerin consumption at week 4 (odds ratio (OR) = 0.863 and 95% CI: [0.147, 5.077]) or week 8 (OR = 1.426 and 95% CI: [0.211, 9.661]). Two themes in the questionnaire showed significantly different changes from baseline between the two groups. Scores on the angina frequency (AF) subscale had changed more from the baseline in the HSG at week 8 than in the LSG (mean difference (MD) = 3.807 and 95% CI: [0.673, 6.942]). Scores on the treatment satisfaction (TS) subscale had also changed more in the HSG than in the LSG at week 4 (MD = 3.651 and 95% CI: [0.327, 7.327]) and week 8 (MD = 4.220 and 95% CI: [0.347, 7.346]). One patient in the LSG reported bruising at the acupoint. No unexpected safety problems arose.
conclusionsThis study showed that acupressure at acupoints with high sensitivity to pain may effectively reduce the frequency of stable angina pectoris episodes. This trial is registered with NCT03975140.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.