Evidence map›Paper›PMID 34764984›Full record

ArticleFrontiers in genetics2021

RAB11FIP1: An Indicator for Tumor Immune Microenvironment and Prognosis of Lung Adenocarcinoma from a Comprehensive Analysis of Bioinformatics.

Wenyi Zhang, Ting Chen, Jun Liu, Shali Yu, Lei Liu, Miaosen Zheng, Yifei Liu, Hongbing Zhang, Tingting Bian, Xinyuan Zhao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Wenyi ZhangSchool of Public Health, Nantong University, Nantong, China.
Ting ChenDepartment of Pathology, Affiliated Dongtai Hospital of Nantong University, Dongtai, China.
Jun LiuThe Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Shali YuSchool of Public Health, Nantong University, Nantong, China.
Lei LiuDepartment of Pathology, Affiliated Hospital of Nantong University, Nantong, China.
Miaosen ZhengDepartment of Pathology, Affiliated Hospital of Nantong University, Nantong, China.
Yifei LiuDepartment of Pathology, Affiliated Hospital of Nantong University, Nantong, China.
Hongbing ZhangJiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Tingting BianSchool of Public Health, Nantong University, Nantong, China.
Xinyuan ZhaoSchool of Public Health, Nantong University, Nantong, China.
Affiliated Hospital of Nantong University · CNNantong University · CNJiangsu Provincial Center for Disease Control and Prevention · CNSixth Affiliated Hospital of Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung adenocarcinoma (LUAD) was the first one all over the world. RAB11FIP1 was found to be expressed differently in a critical way among different cancers. However, the prognostic value and immune infiltration of RAB11FIP1 expression in LUAD are unclear. In this study, the expression of RAB11FIP1 in LUAD was investigated in the Oncomine, TCGA, GEO, and UALCAN databases. Kaplan-Meier analysis was chosen to compare the association between RAB11FIP1 expression and overall survival (OS) in LUAD patients. The dataset of TCGA was used to analyze the pertinence between RAB11FIP1 and clinicpathological factors. GO, KEGG, and network analysis of protein-protein interactions (PPI) were conducted to investigate the potential mechanism of RAB11FIP1. In the end, the relevance of RAB11FIP1 to cancer-immune infiltrates was investigated. RAB11FIP1 was found to be down-regulated by tumors compared with adjacent normal tissue in multiple LUAD cohorts. RAB11FIP1 is an independent prognostic factor in lung adenocarcinoma. There was a high correlation between low RAB11FIP1 in tumors and worse OS in LUAD. Functional network analysis suggested that RAB11FIP1 was associated with multiple pathways. Besides, the expression of RAB11FIP1 was closely related to the infiltration levels of B cell, CD8

Indexed as

bioinformatic analysiscancer immune infiltrateslung adenocarcinomaprognosisRAB11FIP1

Identifiers

PMID34764984
PMCPMC8576257
OpenAlexW3210469442

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.