ReviewSaudi journal of anaesthesia
The hypoxic pulmonary vasoconstriction: From physiology to clinical application in thoracic surgery.
Review in Saudi journal of anaesthesia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06505772 (Dexmedetomidine Improves Oxygenation and Reduces Pulmonary Shunt in High-Risk Pediatric Patients Undergoing One-Lung Ventilation for Thoracic Surgery), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dexmedetomidine Improves Oxygenation and Reduces Pulmonary Shunt in High-Risk Pediatric Patients Undergoing One-Lung Ventilation for Thoracic Surgery: A Double-Blind Randomized Controlled Trial at Damascus University Children's Hospital
Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Effects of phenylephrine and norepinephrine with restrictive infusion on oxygenation during one-lung ventilation for lung surgery: a randomized controlled trial.Annals of medicine · 2026Trial
- Effects of various hypoxic preconditioning strategies on arterial oxygenation in patients undergoing one-lung ventilation during thoracoscopic surgery: a randomized clinical trial.BMC pulmonary medicine · 2026Trial
- Comparison of remimazolam and sevoflurane on arterial oxygenation during one-lung ventilation in thoracoscopic surgery: a randomized controlled trial.Korean journal of anesthesiology · 2025Trial
- Pulmonary vascular changes after lung resection: why less may be more.General thoracic and cardiovascular surgery · 2026Review
- Article
- Association of anesthetic technique with mortality and morbidity in patients undergoing surgery with one-lung ventilation under general anaesthesia.Journal of thoracic disease · 2026Article
- Incidence and Risk Factors for Postoperative Delirium Following Robotic and Video-Assisted Pulmonary Lobectomy: Analysis of the Nationwide Inpatient Sample, 2005-2020.Clinical epidemiology · 2026Article
- Tailored single-lung ventilation approaches and postoperative pulmonary outcomes in thoracic surgery.Journal of thoracic disease · 2025Review
- Mechanical Protective Ventilation: New Paradigms in Thoracic Surgery.Journal of clinical medicine · 2025Review
- Factors influencing sepsis associated thrombocytopenia (SAT): A multicenter retrospective cohort study.PloS one · 2025Observational
- Chinese Herbal Medicine in Hypoxic Pulmonary Hypertension Treatment: Mechanisms, Progress, and Future Directions.Drug design, development and therapy · 2025Review
- Tracheal intubation in the lateral position in emergency medicine: a narrative review and clinical protocol.World journal of emergency medicine · 2025Review
- Article
- Article
- Effects of ultrasound-guided stellate ganglion block on intrapulmonary shunt and oxygenation in patients with single-lung ventilation.Frontiers in surgery · 2024Article
- Hypoxaemia during one lung ventilation.BJA education · 2023Review
- Inhaled Sedation with Volatile Anesthetics for Mechanically Ventilated Patients in Intensive Care Units: A Narrative Review.Journal of clinical medicine · 2023Review
- Hypoxemia in thoracoscopic lung resection surgery using a video double-lumen tube versus a conventional double-lumen tube: A propensity score-matched analysis.Frontiers in surgery · 2023Article
- Pulmonary functions and anthropometric parameters of young male and female adults participating in moderate aerobic exercise.Current research in physiology · 2023Article
- Anesthetic (r)evolution from the conventional concept to the minimally invasive techniques in thoracic surgery-narrative review.Journal of thoracic disease · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More than 70 years after its original report, the hypoxic pulmonary vasoconstriction (HPV) response continues to spark scientific interest on its mechanisms and clinical implications, particularly for anesthesiologists involved in thoracic surgery. Selective airway intubation and one-lung ventilation (OLV) facilitates the surgical intervention on a collapsed lung while the HPV redirects blood flow from the "upper" non-ventilated hypoxic lung to the "dependent" ventilated lung. Therefore, by limiting intrapulmonary shunting and optimizing ventilation-to-perfusion (V/Q) ratio, the fall in arterial oxygen pressure (PaO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.