ArticleSaudi journal of biological sciences2021
Association of TNF-α polymorphisms (-857, -863 and -1031), TNF-α serum level and lipid profile with acne vulgaris.
Article in Saudi journal of biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Alterations in the lipid profile in acne vulgaris patients: A meta-analysis.The Journal of international medical research · 2026Pooled it
- Enhancing Antibacterial Activity ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Human genetic variations conferring resistance to malaria.Journal of translational medicine · 2025Review
- In severe acne vulgaris, TNF-α gene variants are connected to increased TNF-α gene expression and insulin resistance.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Current perspectives for metabolomics and lipidomics in dyslipidemia of acne vulgaris: a mini review.Frontiers in medicine · 2024Review
- Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis.Epigenetics · 2023Article
- Anti-inflammatory effects of banana (Journal of Taibah University Medical Sciences · 2023Article
- Selected hormone levels and lipid abnormalities in patients withPostepy dermatologii i alergologii · 2023Article
- Integration of Single-Cell Transcriptomics Data Reveal Differences in Cell Composition and Communication in Acne.Clinical, cosmetic and investigational dermatology · 2023Article
- Genetic Variants Associated with Acne Vulgaris.International journal of general medicine · 2023Review
- A review of skin immune processes in acne.Frontiers in immunology · 2023Review
- A narrative review of research progress on the role ofAnnals of translational medicine · 2022Review
- Acne Comorbidities.Clinical, cosmetic and investigational dermatology · 2022Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcne is an inflammatory condition principally affected by genetic and dietary factors. Investigation into functional polymorphisms of TNF-α gene and their association with acne vulgaris will be helpful in exploring genetic influence on skin immune mediated inflammatory events. In the present study, we analyzed association of TNF-α gene polymorphisms, its expression levels and lipid profiles in a large cohort of acne patients and controls.
methodsWe used PCR-RFLP to study association of TNF-α polymorphisms at -857C/T, -863C/A and -1031 T/C sites with acne vulgaris. Lipid profiles were measured using enzymatic end-point method. The serum levels of TNF-α and apolipoprotein a were measured using ELISA. NIH, LDlink was used to investigate patterns of linkage disequilibrium across south Asian reference genome (Punjabi from Lahore Pakistan).
resultsWe found that TNF-α -863 polymorphism is strongly associated with acne in overall population as well as in gender and severity based groups of acne patients. Polymorphisms at -863 and -1031 position were in linkage disequilibrium. Importantly, TNF-α serum level was significantly increased in acne patients with severe disease symptoms. Furthermore, levels of total cholesterol (TC) and triglycerides (TG) were significantly increased, whereas high density lipoprotein cholesterol (HDL-C) level was significantly decreased in acne patients. The levels of apolipoprotein a varied widely in studied populations and no significant difference was found in the analyzed groups.
conclusionIn conclusion, we found that TNF-α expression increases in acne patients affected by TNF-α polymorphisms, and that the lipid profile is specifically disrupted in acne patients.
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