Trial reportDrug design, development and therapy2021
Efficacy of Pre-Treatment with Remimazolam on Prevention of Propofol-Induced Injection Pain in Patients Undergoing Abortion or Curettage: A Prospective, Double-Blinded, Randomized and Placebo-Controlled Clinical Trial.
Trial report in Drug design, development and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Efficacy and safety of remimazolam for sedation during gynaecologic procedures: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Comparison of the safety of remimazolam and propofol during general anesthesia in elderly patients: systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Remimazolam versus propofol for sedation in gastrointestinal endoscopy and colonoscopy within elderly patients: a meta-analysis of randomized controlled trials.European journal of clinical pharmacology · 2024Pooled it
- The safety of remimazolam versus propofol in gastroscopic sedation: a meta-analysis.BMC anesthesiology · 2024Pooled it
- ED50 and ED95 of remimazolam for loss of consciousness in young children: a dose-finding study for induction of anaesthesia.British journal of anaesthesia · 2025Trial
- [Comparison of clinical effects and safety of remidazolam and esketamine for preoperative sedation in children].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Trial
- Efficacy of pretreatment with remimazolam on prevention of propofol-induced injection pain in patients undergoing gastroscopy.Scientific reports · 2023Trial
- Remimazolam versus propofol in combination with esketamine for surgical abortion: A double-blind randomized controlled trial.Clinical and translational science · 2023Trial
- Trial
- Effect of different doses of esketamine compared with fentanyl combined with propofol on hypotension in patients undergoing painless abortion surgery: a prospective, randomized, double-blind controlled clinical trial.BMC anesthesiology · 2022Trial
- Effect of Remimazolam Tosilate on Respiratory Depression in Elderly Patients Undergoing Gastroscopy: A Multicentered, Prospective, and Randomized Study.Drug design, development and therapy · 2022Trial
- Efficacy and safety of remimazolam versus propofol in elderly patients undergoing gastrointestinal endoscopy: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2026Article
- The impact of remimazolam sedation during neuraxial anesthesia on perioperative cognitive function in elderly patients: a multicenter randomized controlled study.Frontiers in pharmacology · 2025Article
- Chloroprocaine EDJournal of pain research · 2025Article
- The occurrence of propofol injection pain in the emergency department: an exploratory analysis.World journal of emergency medicine · 2025Article
- EDFrontiers in medicine · 2024Article
- Drug-drug interaction study of ciprofol and sodium divalproex: Pharmacokinetics, pharmacodynamics, and safety in healthy Chinese subjects.Clinical and translational science · 2023Article
- The median effective dose of propofol combined with butorphanol during artificial abortion: a randomized controlled trial.Frontiers in medicine · 2023Article
- Evaluating efficacy and safety of sub-anesthetic dose esketamine as an adjuvant to propofol/remifentanil analgosedation and spontaneous respiration for children flexible fibreoptic bronchoscopy: a prospective, double-blinded, randomized, and placebo-controlled clinical trial.Frontiers in pharmacology · 2023Article
- Remimazolam: An Updated Review of a New Sedative and Anaesthetic.Drug design, development and therapy · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPropofol-induced injection pain (PIP) is a well-known problem in general anesthesia. We hypothesized that pre-treatment with remimazolam prevents PIP in patients undergoing abortion or curettage. MATERIALS AND
methodsIn this prospective, single-center, double-blinded, randomized, placebo-controlled clinical trial, adult patients aged 18 to 60 undergoing abortion or curettage were randomly assigned to three groups. Group Lido received system lidocaine (a bolus of 0.5 mg kg
resultsThe incidence of patients with PIP was higher in group NS than that in group Lido and group Remi (75.7, 44.3, and 42.9%, respectively,
conclusionOur findings indicate that pre-treatment with remimazolam reduced the incidence and intensity of PIP in abortion or curettage patients, equivalent to that of lidocaine without severe adverse effects.
trial registrationChinese Clinical Trial Registry (identifier: ChiCTR2100041805).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.