Evidence map›Paper›PMID 34764633›Full record

ReviewBiologics : targets & therapy2021

State-of-the-Art of Monoclonal Antibodies for the Treatment of Gastric Cancer.

Debora Basile, Francesca Simionato, Alessandro Cappetta, Silvio Ken Garattini, Giandomenico Roviello, Giuseppe Aprile

Abstract readReview
In one paragraph

Review in Biologics : targets & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Debora BasileDepartment of Oncology, San Bortolo General Hospital, AULSS8 Berica, Vicenza, Italy.
Francesca SimionatoDepartment of Oncology, San Bortolo General Hospital, AULSS8 Berica, Vicenza, Italy.
Alessandro CappettaDepartment of Oncology, San Bortolo General Hospital, AULSS8 Berica, Vicenza, Italy.ORCID 0000-0002-2147-2790
Silvio Ken GarattiniDepartment of Oncology, University Hospital, Udine, Italy.
Giandomenico RovielloDepartment of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Firenze, Firenze, Italy.
Giuseppe AprileDepartment of Oncology, San Bortolo General Hospital, AULSS8 Berica, Vicenza, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) is a complex and heterogeneous disease with poor prognosis and limited available treatment options. During recent years, several molecular stratifications have been proposed to optimize the overall treatment strategy for GC patients. Breakthroughs in cancer biology and in molecular profiling through DNA and RNA sequencing are now opening novel landscapes, leading to the personalization of molecular matched therapy. In particular, therapies against HER2, Claudine 18.2, Fibroblast Growth Factor Receptors (FGFR), and other molecular alterations could significantly improve survival outcomes in the advance phase of the disease. Furthermore, immunotherapy with checkpoint inhibitors also represents a promising option in a selected population. Hoping that precision oncology will enter soon in clinical practice, our review describes the state of the art of many novel pathways and the current evidence supporting the use of monoclonal antibodies implicated in GC treatment.

Indexed as

Claudine 18.2 inhibitorsFGFR inhibitorsgastric cancerHER2-inhibitorsprecision oncology

Identifiers

PMID34764633
PMCPMC8572727

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.