Evidence map›Paper›PMID 34764491›Full record

ArticleNature biotechnology2022

A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo.

Ao Dong, Kaikai He, Barna Dudok, Jordan S Farrell, Wuqiang Guan, Daniel J Liput, Henry L Puhl, Ruyi Cai, Huan Wang, Jiali Duan and 6 more

Open access · greenAbstract read
In one paragraph

Article in Nature biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed
20.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 180 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Unraveling Endocannabinoid Signaling Pathways in Cisplatin-Induced Ototoxicity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  10. Genetically Encoded CBInternational journal of molecular sciences · 2026
    Article
  11. Review
  12. Review
  13. Astrocyte CBJournal of neuroinflammation · 2026
    Article
  14. Article
  15. Review
  16. Genetic Tools in Rodents to Study Cannabinoid Functions.Current topics in behavioral neurosciences · 2026
    Review
  17. Article
  18. Review
  19. Article
  20. Review

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Ao DongState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-2821-9528
Kaikai HeState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-2002-4862
Barna DudokDepartment of Neurosurgery, Stanford University, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0001-5078-0090
Jordan S FarrellDepartment of Neurosurgery, Stanford University, Palo Alto, CA, USA.
Wuqiang GuanCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Daniel J LiputLaboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Henry L PuhlLaboratory of Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-3095-7201
Ruyi CaiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Huan WangState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Jiali DuanState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Eddy AlbarranNeuroscience PhD Program, Stanford University, Palo Alto, CA, USA.
Jun DingDepartment of Neurosurgery, Department of Neurology, Stanford University School of Medicine, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-0690-1312
David M LovingerLaboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Bo LiCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Ivan SolteszDepartment of Neurosurgery, Stanford University, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-1493-3744
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China. yulongli@pku.edu.cn.ORCID http://orcid.org/0000-0002-9166-9919
Peking University · CNStanford University · USNational Institute on Alcohol Abuse and Alcoholism · USCold Spring Harbor Laboratory · USMcGovern Institute for Brain Research · USPalo Alto University · US

Funding

Synaptic Transmission: Modulation, Plasticity And Effects Of Drugs Of AbuseZIAAA000407 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LOVINGER, DAVID M · 2009 to 2025
$29.6M
Corticostriatal mechanisms of action learning and habit formationZIAAA000416 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LOVINGER, DAVID M · 2009 to 2025
$25.2M
Research Supplement to Promote Diversity in Health-Related ResearchR01MH101377 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dayu Lin · 2013 to 2026
$8.6M
The central amygdala circuits in motivated behaviorsR01MH101214 · NIMH · COLD SPRING HARBOR LABORATORY · PI VAN AELST, LINDA · 2014 to 2024
$6.3M
Multiplex imaging of neuronal activity and signaling dynamics underlying learning in discrete amygdala circuits of behaving mice.R01NS104944 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LI, BO, MAO, TIANYI · 2018 to 2022
$5.0M
Novel fluorescent sensors for imaging neuromodulationU01NS113358 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI DAN, YANG, LI, YULONG · 2019 to 2022
$4.3M
Cannabinoid control of epilepsyR01NS099457 · NINDS · STANFORD UNIVERSITY · PI SOLTESZ, IVAN · 2017 to 2021
$1.8M
Perisomatic inhibition in epilepsyK99NS117795 · NINDS · STANFORD UNIVERSITY · PI DUDOK, BARNA · 2020 to 2021
$177k
CIHRIntramural NIH HHS ZIA AA000416NIMH NIH HHS R01 MH101214NIMH NIH HHS R01 MH101377NINDS NIH HHS K99 NS117795NINDS NIH HHS R01 NS099457NINDS NIH HHS R01 NS104944NINDS NIH HHS U01 NS113358
6 · The paper itself

Abstract

Endocannabinoids (eCBs) are retrograde neuromodulators with important functions in a wide range of physiological processes, but their in vivo dynamics remain largely uncharacterized. Here we developed a genetically encoded eCB sensor called GRAB

Indexed as

EndocannabinoidsNeuronsAnimalsBrainHippocampusMiceSignal TransductionEndocannabinoids

Identifiers

PMID34764491
PMCPMC9091059
OpenAlexW3214293964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.