ArticleNature immunology2022
Autocrine vitamin D signaling switches off pro-inflammatory programs of T
Open access · bronzeAbstract read
In one paragraph
Article in Nature immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 7 pooled it
22.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
133 citing papers in PubMed, 7 syntheses or guidelines pooled it, 197 citations in OpenAlex.
- Efficacy and safety of vitamin D supplementation in treating pulmonary tuberculosis: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Vitamin D Deficiency Meets Hill's Criteria for Causation in SARS-CoV-2 Susceptibility, Complications, and Mortality: A Systematic Review.Nutrients · 2025Pooled it
- Pooled it
- Pooled it
- Pooled it
- The Vitamin D Serum Levels in Pregnant Women Affected by COVID-19: A Systematic Review and Meta-Analysis.Nutrients · 2023Pooled it
- Vitamin D and adrenal gland: Myth or reality? A systematic review.Frontiers in endocrinology · 2022Pooled it
- Trial
- Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT).BMJ (Clinical research ed.) · 2022Trial
- 25-Hydroxyvitamin D Sufficiency Is Associated With Reduced Atelectasis in Common Variable Immunodeficiency: A Cross-Sectional Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Skeletal muscle H3K18 lactylation inhibits hepatic gluconeogenesis through IL-6 mediated interorgan communication.Science advances · 2026Article
- An Agonist/Antagonist Photo-Switchable Vitamin D Mimetic Enables Bidirectional Optical Control of VDR.Angewandte Chemie (International ed. in English) · 2026Article
- Th2 and Th17/Th1 Inflammatory Profiles in Chronic Rhinosinusitis: Associations with Vitamin D Status and Disease Severity.International journal of molecular sciences · 2026Article
- Vitamin D as a cellular endocrine system: Tissue-specific microcircuits, immune reprogramming, and metabolic resistance.iScience · 2026Review
- Impact of Vitamin D3 Supplementation on 28-Day ICU Mortality in Sepsis Patients: A Retrospective Study with Propensity Score Matching.Pathogens (Basel, Switzerland) · 2026Article
- Vitamin D in Gut and Systemic Immune Tolerance and in Infections' Risk: An International Evidence-Based Consensus Statement.Reviews in endocrine & metabolic disorders · 2026Review
- Integrated omics reveal the effects of vitamin D deficiency on gut microbiota and plasma metabolism in experimental autoimmune uveitis.Journal of neuroinflammation · 2026Article
- Synergistic Anticancer Effects of Vitamin D and Plant-Derived Compounds: Molecular Mechanisms, Therapeutic Potential, and Nanotechnology-Enabled Delivery Approaches.International journal of molecular sciences · 2026Review
- The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications.Journal of cell communication and signaling · 2026Review
73 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
29 authors at 7 institutions in 5 countries.
Daniel Chauss *Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.
Tilo Freiwald *Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-4759-717X
Reuben McGregor *Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0684-7635
Bingyu Yan *Department of Biochemistry, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0003-4429-8200
Luopin Wang *Department of Computer Science, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0001-5758-4092
Estefania Nova-LampertiMolecular and Translational Immunology Laboratory, Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, Universidad de Concepcion, Concepcion, Chile.ORCID http://orcid.org/0000-0002-7673-0013
Dhaneshwar KumarImmunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.
Zonghao ZhangDepartment of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA.
Heather TeagueLaboratory of Inflammation & Cardiometabolic Diseases, Cardiovascular Branch, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, MD, USA.
Erin E WestComplement and Inflammation Research Section, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, MD, USA.
Kevin M VannellaLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA.
Marcos J Ramos-BenitezLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA.
Jack BibbyComplement and Inflammation Research Section, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, MD, USA.
Audrey KellyPeter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Amna MalikDepartment of Medicine, Imperial College London, London, UK.
Alexandra F FreemanLaboratory of Clinical Immunology & Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA.
Daniella M SchwartzLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA.
Didier PortillaImmunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.
Daniel S ChertowLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA.
Susan JohnPeter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5620-1982
Paul LavenderPeter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Claudia KemperComplement and Inflammation Research Section, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-4196-1417
Giovanna LombardiPeter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID http://orcid.org/0000-0003-4496-3215
Nehal N MehtaLaboratory of Inflammation & Cardiometabolic Diseases, Cardiovascular Branch, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, MD, USA.
Nichola CooperDepartment of Medicine, Imperial College London, London, UK.
Michail S LionakisFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-4994-9500
Arian LaurenceNuffield Department of Medicine, University of Oxford, Oxford, UK.
Majid KazemianDepartment of Biochemistry, Purdue University, West Lafayette, IN, USA. kazemian@purdue.edu.ORCID http://orcid.org/0000-0001-7080-8820
Behdad AfzaliImmunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA. behdad.afzali@nih.gov.ORCID http://orcid.org/0000-0003-2968-1156
National Institutes of Health · USKing's College London · GBPurdue University West Lafayette · USImperial College London · GBGoethe University Frankfurt · DEUniversity of Concepción · CLUniversity of Oxford · GB
Funding
Human Translational Studies of Inflammation and Cardiometabolic Diseases: The Psoriasis, Atherosclerosis and Cardiometabolic disease (PACI) InitiativeZIAHL006193 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SACK, MICHAEL · 2014 to 2023
$25.0MImmunopathogenesis of Fungal InfectionsZIAAI001175 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LIONAKIS, MICHAIL · 2012 to 2025
$23.9MUnravelling immunoregulatory circuits of tissue inflammationZIADK075149 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI AFZALI, BEHDAD · 2019 to 2025
$19.3MThe role of the intracellular complement system - the complosome - in Th1 biologyZIAHL006223 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KEMPER, CLAUDIA · 2017 to 2025
$16.9MPrimary Immune Deficiency ClinicZIAAI001247 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FREEMAN, ALEXANDRA · 2019 to 2025
$8.7MIn-vitro and Pre-clinical Translational Studies of Inflammation and AtherosclerosisZIAHL006235 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SACK, MICHAEL · 2018 to 2023
$6.7MJoint submission for administrative supplement proposal: HIPAA aligned storage and computing solutionR35GM138283 · NIGMS · PURDUE UNIVERSITY · PI KAZEMIAN, MAJID · 2020 to 2024
$2.0MRole of intracellular complement activation in kidney fibrosisR01DK122624 · NIDDK · UNIVERSITY OF VIRGINIA · PI PORTILLA, DIDIER · 2020 to 2022
$727kThe pathogenesis of COVID-19ZIAAI001318 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LIONAKIS, MICHAIL · 2020 to 2023
$290kThe role of complement in COVID-19 ZIAHL006254 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KEMPER, CLAUDIA · 2020 to 2022
$203kT cell responses in MIS-C related to SARS-CoV2ZIAAI001274 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SCHWARTZ, DANIELLA · 2020 to 2022
$71kClinical and Molecular Features of Coronavirus Disease 2019ZIACL090070 · CLC · CLINICAL CENTER · PI CHERTOW, DANIEL S · 2020 to 2025
$0kBritish Heart Foundation RG/13/12/30395British Heart Foundation (BHF) RG/13/12/30395Crohn's and Colitis Foundation (Crohn's & Colitis Foundation) CCFA no. 3765Deutsche Forschungsgemeinschaft (German Research Foundation) FR 3851/2-1Intramural NIH HHS ZIA AI001175Intramural NIH HHS ZIA DK075149Intramural NIH HHS ZIA HL006193NIDDK NIH HHS R01 DK122624NIGMS NIH HHS R35 GM138283U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) ZIA/HL006193U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) ZIA/Hl00622U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) ZIA/Hl006223U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) ZIA/AI00117U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) ZIA/AI001175U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK12262401A1U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) ZIA/DK075149U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM138283Wellcome TrustWellcome Trust (Wellcome) 097261/Z/11/Z
Abstract
The molecular mechanisms governing orderly shutdown and retraction of CD4
Indexed as
25-Hydroxyvitamin D3 1-alpha-HydroxylaseBasic-Leucine Zipper Transcription FactorsBronchoalveolar Lavage FluidComplement C3aComplement C3bCOVID-19HumansInterferon-gammaInterleukin-10JNK Mitogen-Activated Protein KinasesLymphocyte ActivationReceptors, CalcitriolRespiratory Distress SyndromeSARS-CoV-2Signal TransductionSTAT3 Transcription Factor25-Hydroxyvitamin D3 1-alpha-HydroxylaseBACH2 protein, humanBasic-Leucine Zipper Transcription FactorsComplement C3aComplement C3bCYP27B1 protein, humanIFNG protein, humanIL10 protein, humanInterferon-gammaInterleukin-10JNK Mitogen-Activated Protein KinasesReceptors, CalcitriolSTAT3 protein, humanSTAT3 Transcription FactorVDR protein, humanVitamin D
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What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.