Evidence map›Paper›PMID 34764368›Full record

ArticleScientific reports2021

Spontaneous pulmonary emphysema in mice lacking all three nitric oxide synthase isoforms.

Kaori Kato, Masato Tsutsui, Shingo Noguchi, Yukitoshi Iha, Keisuke Naito, Takaaki Ogoshi, Chinatsu Nishida, Masahiro Tahara, Hirotaka Yamashita, Ke-Yong Wang and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Preclinical models of COPD: a state of the art review.The European respiratory journal · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Kaori KatoDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Masato TsutsuiDepartment of Pharmacology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan. tsutsui@med.u-ryukyu.ac.jp.
Shingo NoguchiDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Yukitoshi IhaDepartment of Pharmacology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan.
Keisuke NaitoDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Takaaki OgoshiDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Chinatsu NishidaDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Masahiro TaharaDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Hirotaka YamashitaDepartment of Pharmacology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan.
Ke-Yong WangShared-Use Research Center, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Yumiko ToyohiraDepartment of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Nobuyuki YanagiharaDepartment of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Hiroaki MasuzakiSecond Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Hiroaki ShimokawaDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Akihide TanimotoDepartment of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Kazuhiro YateraDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
University of Occupational and Environmental Health Japan · JPUniversity of the Ryukyus · JPKagoshima University · JPTohoku University · JP

Funding

Glaxo Smith Kline (GSK) Japan Research Grant 2018 7188022JSPS KAKENHI JP16K09519
6 · The paper itself

Abstract

The roles of endogenous nitric oxide (NO) derived from the entire NO synthases (NOSs) system have yet to be fully elucidated. We addressed this issue in mice in which all three NOS isoforms were deleted. Under basal conditions, the triple n/i/eNOSs

Indexed as

AnimalsDisease Models, AnimalDown-RegulationGene ExpressionMaleMiceMice, Inbred C57BLMice, KnockoutNitric Oxide SynthaseProtein IsoformsPulmonary EmphysemaRNA, MessengerSignal TransductionNitric Oxide SynthaseProtein IsoformsRNA, Messenger

Identifiers

PMID34764368
PMCPMC8586362
OpenAlexW3211398113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.