ArticleScientific reports2021
Changes in white matter microstructure and MRI-derived cerebral blood flow after 1-week of exercise training.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- The effect of exercise on cerebral blood flow and executive function among young adults: a double-blinded randomized controlled trial.Scientific reports · 2023Trial
- The importance of cross-talk in research and the body: An early career researcher perspective.Experimental physiology · 2026Article
- Enhanced Brain Connectivity Following Six Weeks of Upper Extremity Offset Loading in Neurotypical Adults-A Preliminary Study.Sensors (Basel, Switzerland) · 2026Article
- Resting Cerebrovascular Haemodynamics and Dynamic Assessment of Cerebrovascular Function in Polycystic Ovary Syndrome.Clinical endocrinology · 2026Article
- Non-invasive visual theta entrainment modulates myelin-related and functional outcomes in an LPC-induced demyelination model.PloS one · 2026Article
- Correlation between hemodynamic characterizations of cervical arteries and changes in cerebral microcirculation under dobutamine stress: a self-controlled study.BMC medical imaging · 2025Article
- Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI.Experimental physiology · 2025Review
- Brain basis for physical activity levels mediate beta Inhibition to improve cognitive function in elderly based on multimodality monitoring.Scientific reports · 2025Article
- Modulation and distribution of extracellular free water and tract deficits in rhesus macaques before and after the initiation of emtricitabine + tenofovir disoproxil fumarate + dotutegravir treatment.Frontiers in immunology · 2025Article
- Article
- Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation.eLife · 2023Article
- Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation.bioRxiv : the preprint server for biology · 2023Article
- Muscle-to-Brain Signaling Via Myokines and Myometabolites.Brain plasticity (Amsterdam, Netherlands) · 2022Review
- The Immediate and Sustained Effects of Moderate-Intensity Continuous Exercise and High-Intensity Interval Exercise on Working Memory.Frontiers in psychology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Exercise is beneficial for brain health, inducing neuroplasticity and vascular plasticity in the hippocampus, which is possibly mediated by brain-derived neurotrophic factor (BDNF) levels. Here we investigated the short-term effects of exercise, to determine if a 1-week intervention is sufficient to induce brain changes. Fifteen healthy young males completed five supervised exercise training sessions over seven days. This was preceded and followed by a multi-modal magnetic resonance imaging (MRI) scan (diffusion-weighted MRI, perfusion-weighted MRI, dual-calibrated functional MRI) acquired 1 week apart, and blood sampling for BDNF. A diffusion tractography analysis showed, after exercise, a significant reduction relative to baseline in restricted fraction-an axon-specific metric-in the corpus callosum, uncinate fasciculus, and parahippocampal cingulum. A voxel-based approach found an increase in fractional anisotropy and reduction in radial diffusivity symmetrically, in voxels predominantly localised in the corpus callosum. A selective increase in hippocampal blood flow was found following exercise, with no change in vascular reactivity. BDNF levels were not altered. Thus, we demonstrate that 1 week of exercise is sufficient to induce microstructural and vascular brain changes on a group level, independent of BDNF, providing new insight into the temporal dynamics of plasticity, necessary to exploit the therapeutic potential of exercise.
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Registered trials
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