ArticleScientific reports2021
Honey bee sHSP are responsive to diverse proteostatic stresses and potentially promising biomarkers of honey bee stress.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 39 citations in OpenAlex.
- Diet Quality Shapes Metabolic and Immune Transcriptional Responses of Honey Bees Under Acute Heat Stress.Insects · 2026Article
- Review
- Exploratory proteomic characterization ofFrontiers in pharmacology · 2026Article
- Evidence for vitellogenin DNA-binding in honey bees.Protein science : a publication of the Protein Society · 2025Article
- Dissection of genetic basis underlying heat stress response of Apis cerana.BMC genomics · 2025Article
- Honey bee (Apis mellifera) queen quality: host-microbial transcriptomes exploring the influence of age and hindgut symbiont Commensalibacter melissae.Animal microbiome · 2025Article
- Remodeling of Cellular Respiration and Insulin Signaling Are Part of a Shared Stress Response in Divergent Bee Species.Insects · 2025Article
- In the battle of survival: transcriptome analysis of hypopharyngeal gland of the Apis mellifera under temperature-stress.BMC genomics · 2025Article
- Leveraging Transcriptional Signatures of Diverse Stressors for Bumble Bee Conservation.Molecular ecology · 2025Article
- Climate change-induced stress in the honey beeFrontiers in physiology · 2025Review
- Article
- Stress drives premature hive exiting behavior that leads to death in young honey bee (Apis mellifera) workers.Biological research · 2024Article
- Based proteomics analyses reveal response mechanisms of Apis mellifera (Hymenoptera: Apidae) against the heat stress.Journal of insect science (Online) · 2024Article
- Transcriptional control of a metabolic switch regulating cellular methylation reactions is part of a common response to stress in divergent bee species.The Journal of experimental biology · 2024Article
- Regulatory roles of long non-coding RNAs in short-term heat stress in adult worker bees.BMC genomics · 2024Article
- Bleomycin reducesMicrobiology spectrum · 2024Article
- Article
- Applying Artificial Neural Networks to Oxidative Stress Biomarkers in Forager Honey Bees (Toxics · 2023Article
- Indirect exposure to insect growth disruptors affects honey bee (Apis mellifera) reproductive behaviors and ovarian protein expression.PloS one · 2023Article
- Using the Honey Bee (Apis mellifera L.) Cell Line AmE-711 to Evaluate Insecticide Toxicity.Environmental toxicology and chemistry · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pollination services provided by the honey bee are critical in both natural and agricultural ecosystems. Honey bee colonies in the United States have suffered from an increased rate of die-off in recent years, stemming from a complex set of interacting stresses that remain poorly described. Defining specific common cellular processes and cellular stress responses impacted by multiple stressors represent a key step in understanding these synergies. Proteotoxic stresses negatively impact protein synthesis, folding, and degradation. Diverse proteotoxic stresses induce expression of genes encoding small heat shock proteins (sHSP) of the expanded lethal (2) essential for life (l(2)efl) gene family. In addition to upregulation by the Integrated Stress Response (ISR), the Heat Shock Response (HSR), and the Oxidative Stress Response (OSR), our data provide first evidence that sHSP genes are upregulated by the Unfolded Protein Response (UPR). As these genes appear to be part of a core stress response that could serve as a useful biomarker for cellular stress in honey bees, we designed and tested an RT-LAMP assay to detect increased l(2)efl gene expression in response to heat-stress. While this assay provides a powerful proof of principle, further work will be necessary to link changes in sHSP gene expression to colony-level outcomes, to adapt our preliminary assay into a Point of Care Testing (POCT) assay appropriate for use as a diagnostic tool for use in the field, and to couple assay results to management recommendations.
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