ArticleNPJ Parkinson's disease2021
Distinct patterns of speech disorder in early-onset and late-onset de-novo Parkinson's disease.
Article in NPJ Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- Digital measurement of ocular microtremor in Parkinson's Disease: Analytical and clinical validation.PLOS digital health · 2026Article
- From phenotype to biology: a multi-modal roadmap of biofluid, tissue, imaging, and digital biomarkers in Parkinson's disease.Translational neurodegeneration · 2026Review
- Aerodynamic and Acoustic Characteristics of Nasal Airflow in Parkinson's Disease.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Alpha-synuclein overexpression reduces neural activity within a basal ganglia vocal nucleus in a zebra finch model.PloS one · 2026Article
- Exploring Bidirectional Associations Between Voice Acoustics and Objective Motor Metrics in Parkinson's Disease.Brain sciences · 2025Article
- ParkMAE: a cross-linguistic masked autoencoder framework for robust Parkinson's disease detection from speech.Scientific reports · 2025Article
- Voice fundamental characteristics in Parkinson's disease: a case-control study of the Moroccan population.Neurodegenerative disease management · 2025Article
- Perceptions of neuromuscular electrostimulation of patients with Parkinson's disease and their caregivers: the impact on swallowing and speech from a qualitative perspective.Journal of patient-reported outcomes · 2025Article
- Age-Associated Cortical Thinning in Speech Motor Regions Precedes Hippocampal Decline: Implications for Alzheimer's Disease.Human brain mapping · 2025Article
- Digital speech biomarkers can measure acute effects of levodopa in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Investigation of the voice handicaps in Parkinson's disease and determination of the clinical correlates.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Smartphone-derived multidomain features including voice, finger-tapping movement and gait aid early identification of Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Automatic speech analysis combined with machine learning reliably predicts the motor state in people with Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Normative aging results in degradation of gene networks in a zebra finch basal ganglia nucleus dedicated to vocal behavior.Neurobiology of aging · 2025Article
- Detecting neuropsychiatric fluctuations in Parkinson's Disease using patients' own words: the potential of large language models.NPJ Parkinson's disease · 2025Article
- A cross-language speech model for detection of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Speech and language biomarkers for Parkinson's disease prediction, early diagnosis and progression.NPJ Parkinson's disease · 2025Review
- Vocal Feature Changes for Monitoring Parkinson's Disease Progression-A Systematic Review.Brain sciences · 2025Review
- Is self-perception related to speech perceptual analysis measures in early- and late-onset Parkinson's disease?Dementia & neuropsychologia · 2025Article
- In Silico Decoding of Parkinson's: Speech & Writing Analysis.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Substantial variability and severity of dysarthric patterns across Parkinson's disease (PD) patients may reflect distinct phenotypic differences. We aimed to compare patterns of speech disorder in early-onset PD (EOPD) and late-onset PD (LOPD) in drug-naive patients at early stages of disease. Speech samples were acquired from a total of 96 participants, including two subgroups of 24 de-novo PD patients and two subgroups of 24 age- and sex-matched young and old healthy controls. The EOPD group included patients with age at onset below 51 (mean 42.6, standard deviation 6.1) years and LOPD group patients with age at onset above 69 (mean 73.9, standard deviation 3.0) years. Quantitative acoustic vocal assessment of 10 unique speech dimensions related to respiration, phonation, articulation, prosody, and speech timing was performed. Despite similar perceptual dysarthria severity in both PD subgroups, EOPD showed weaker inspirations (p = 0.03), while LOPD was characterized by decreased voice quality (p = 0.02) and imprecise consonant articulation (p = 0.03). In addition, age-independent occurrence of monopitch (p < 0.001), monoloudness (p = 0.008), and articulatory decay (p = 0.04) was observed in both PD subgroups. The worsening of consonant articulation was correlated with the severity of axial gait symptoms (r = 0.38, p = 0.008). Speech abnormalities in EOPD and LOPD share common features but also show phenotype-specific characteristics, likely reflecting the influence of aging on the process of neurodegeneration. The distinct pattern of imprecise consonant articulation can be interpreted as an axial motor symptom of PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.