ReviewNature reviews. Disease primers2021
Essential tremor.
Review in Nature reviews. Disease primers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 2 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- Deep brain stimulation and magnetic resonance-guided focused ultrasound for essential tremor: a meta-analysis of effectiveness and safety.Neurosurgical review · 2026Pooled it
- Movement Disorders and Smart Wrist Devices: A Comprehensive Study.Sensors (Basel, Switzerland) · 2025Pooled it
- A Randomized, Double-Blind, Placebo Controlled, Crossover Trial of incobotulinumtoxinA Treatment for Upper Limb Tremor.Movement disorders clinical practice · 2025Trial
- The emerging role of high-intensity focused ultrasound (HIFU) as a symptomatic treatment for Parkinson's disease and essential tremor: a narrative review.Arquivos de neuro-psiquiatria · 2026Review
- Comparative Analysis of Four Commercially Available Artificial Intelligence Software for Brain Volumetry.Diagnostics (Basel, Switzerland) · 2026Article
- Radiomodulation-The Final Frontier of Radiosurgery?Brain sciences · 2026Review
- Epidemiology and Treatment of Patients with Essential Tremor: A Retrospective Cohort Analysis in the United Kingdom.Neuroepidemiology · 2026Article
- Feasibility Pilot of the LaceUp Compression-Weight Sleeve for Essential Tremor.Bioengineering (Basel, Switzerland) · 2026Article
- A transdiagnostic structural brain signature of Parkinsonian and Essential Tremor.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Successful MRgFUS VIM Thalamotomy for Essential Tremor Nearby Cavernous Malformation: Image Case Report.Stereotactic and functional neurosurgery · 2026Article
- Differentiating tremor-dominant parkinson's disease from essential tremor using neuromelanin- sensitive imaging and T1w/T2w ratio.NPJ Parkinson's disease · 2026Article
- An Exploratory Study of Auditory Brainstem Responses and Hearing Thresholds in Essential Tremor.Medicina (Kaunas, Lithuania) · 2026Article
- Functional network reorganization following VIM-MRgFUS for essential tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Prevalence and Impact of Probable REM Sleep Behavior Disorder in Essential Tremor: A Multicenter Cross-Sectional Study.European journal of neurology · 2026Article
- Copy Number Variant Duplications Associated with Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
- Natural disease progression vs. DBS-related worsening in essential tremor.medRxiv : the preprint server for health sciences · 2025Article
- Phenotypical Differentiation of Tremor Using Time Series Feature Extraction and Machine Learning.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Familial adult myoclonus epilepsy: A comprehensive diagnostic strategy for clinical practice.Epilepsia · 2025Review
- Optimizing real-time phase detection in diverse rhythmic biological signals for phase-specific neurostimulation.Journal of neural engineering · 2025Article
- The dual role of PCDH9 in tumors, neurological and developmental diseases.Medical oncology (Northwood, London, England) · 2025Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Essential tremor (ET) is one of the most common movement disorders, with a reported >60 million affected individuals worldwide. The definition and underlying pathophysiology of ET are contentious. Patients present primarily with motor features such as postural and action tremors, but may also have other non-motor features, including cognitive impairment and neuropsychiatric symptoms. Genetics account for most of the ET risk but environmental factors may also be involved. However, the variable penetrance and challenges in validating data make gene-environment analysis difficult. Structural changes in cerebellar Purkinje cells and neighbouring neuronal populations have been observed in post-mortem studies, and other studies have found GABAergic dysfunction and dysregulation of the cerebellar-thalamic-cortical circuitry. Commonly prescribed medications include propranolol and primidone. Deep brain stimulation and ultrasound thalamotomy are surgical options in patients with medically intractable ET. Further research in post-mortem studies, and animal and cell-based models may help identify new pathophysiological clues and therapeutic targets and, together with advances in omics and machine learning, may facilitate the development of precision medicine for patients with ET.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.