ArticleNature communications2021
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
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Who cites it
28 citing papers in PubMed, 37 citations in OpenAlex.
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- ATAD3 duplications bridge mitochondrial diseases and Aicardi-Goutières syndrome.Developmental medicine and child neurology · 2026Article
- Unlocking microglia pyroptosis in a model of type I interferon-driven neuroinflammation: lessons from Rnaset2Cell death & disease · 2025Article
- Mapping Lysosomal Storage Disorders with Neurological Features by Cellular Pathways: Towards Precision Medicine.Current issues in molecular biology · 2025Review
- The lysosomal catabolism of nucleic acids-critical regulators of the innate immune system.Nucleic acids research · 2025Review
- Ribonucleases in Mendelian disease: Characterization and insight from model organisms.Genes & diseases · 2025Review
- Single-Cell mRNA Analysis for the Identification of Molecular Pathways of IRF1 in HER2+ Breast Cancer.Cells · 2025Article
- Innate immune responses to lysosomal nucleic acid stress.Journal of biochemistry · 2025Review
- Spondyloenchondrodysplasia: An enigmatic immuno-osseus type I interferonopathy.Journal of human immunity · 2025Article
- Nucleic acid triggers of autoimmunity and autoinflammation.Current opinion in immunology · 2025Review
- RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells.The Journal of experimental medicine · 2025Article
- RNase T2 restricts TLR13-mediated autoinflammation in vivo.The Journal of experimental medicine · 2025Article
- Genome-wide analysis of the SPL family in Zanthoxylum armatum and ZaSPL21 promotes flowering and improves salt tolerance in transgenic Nicotiana benthamiana.Plant molecular biology · 2025Article
- CNS disease associated with enhanced type I interferon signalling.The Lancet. Neurology · 2024Review
- A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise.Molecular neurobiology · 2024Article
- Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation.Immunity · 2024Article
- The immune response to RNA suppresses nucleic acid synthesis by limiting ribose 5-phosphate.The EMBO journal · 2024Article
- TENT5-mediated polyadenylation of mRNAs encoding secreted proteins is essential for gametogenesis in mice.Nature communications · 2024Article
Corrections and comments
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Authors and funding
28 authors at 7 institutions in 3 countries.
Matthias Kettwig *Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Georg August University, Göttingen, Germany. matthias.kettwig@med.uni-goettingen.de.ORCID http://orcid.org/0000-0003-4804-7716
Katharina Ternka *Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.ORCID http://orcid.org/0000-0003-3773-4625
Kristin WendlandDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.
Dennis Manfred KrügerDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Silvia ZamparDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Georg August University, Göttingen, Germany.ORCID http://orcid.org/0000-0003-0134-0974
Charlotte SchobDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.
Jonas FranzInstitute of Neuropathology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.ORCID http://orcid.org/0000-0001-7523-6622
Abhishek AichDepartment of Cellular Biochemistry, University Medical Center Göttingen, Georg August University, Göttingen, Germany.ORCID http://orcid.org/0000-0001-8331-9874
Anne WinklerInstitute of Neuropathology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.
M Sadman SakibDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Lalit KauraniDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Robert EppleDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Hauke B WernerDepartment of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.ORCID http://orcid.org/0000-0002-7710-5738
Samy HakroushInstitute of Pathology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.
Julia KitzInstitute of Pathology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.
Marco PrinzInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-0349-1955
Eva BartokInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-0556-1950
Gunther HartmannInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Bonn, Germany.
Simone SchröderDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.
Peter RehlingDepartment of Cellular Biochemistry, University Medical Center Göttingen, Georg August University, Göttingen, Germany.
Marco HennekeDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.
Susann BoretiusFunctional Imaging Laboratory, German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany.ORCID http://orcid.org/0000-0003-2792-7423
A AliaInstitute for Medical Physics and Biophysics, University of Leipzig, Leipzig, Germany.
Oliver WirthsDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Georg August University, Göttingen, Germany.ORCID http://orcid.org/0000-0002-4115-0334
Andre FischerDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Christine StadelmannInstitute of Neuropathology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.ORCID http://orcid.org/0000-0003-1766-5458
Stefan NesslerInstitute of Neuropathology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.
Jutta GärtnerDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.
Universitätsmedizin Göttingen · DEGerman Center for Neurodegenerative Diseases · DEUniversity of Bonn · DEGerman Primate Center · DELeiden University · NLMax Planck Institute of Experimental Medicine · DEUniversity of Freiburg · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infantile-onset RNaseT2 deficient leukoencephalopathy is characterised by cystic brain lesions, multifocal white matter alterations, cerebral atrophy, and severe psychomotor impairment. The phenotype is similar to congenital cytomegalovirus brain infection and overlaps with type I interferonopathies, suggesting a role for innate immunity in its pathophysiology. To date, pathophysiological studies have been hindered by the lack of mouse models recapitulating the neuroinflammatory encephalopathy found in patients. In this study, we generated Rnaset2
Indexed as
AnimalsCD8-Positive T-LymphocytesCognitive DysfunctionDisease Models, AnimalEndoribonucleasesFemaleFlow CytometryGenotypeHumansImmunohistochemistryLeukoencephalopathiesMagnetic Resonance ImagingMaleMemory T CellsMiceMice, KnockoutEndoribonucleases
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