ArticleNature communications2021
Nitrate restricts nodule organogenesis through inhibition of cytokinin biosynthesis in Lotus japonicus.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Plant traits explain variation in symbiotic nitrogen fixation responses to global nitrogen enrichment: a meta-analysis.Nature communications · 2026Pooled it
- Peptide hormones in shaping root system architecture and environmental adaptation: Current advances and translational perspectives.Plant communications · 2026Review
- Role of theHorticulture research · 2026Article
- Pea plants conditionally sanction less effectively fixing rhizobia at the level of whole nodules rather than single cells.Journal of experimental botany · 2026Article
- Cytokinin receptor AHK3 influences leaf size by modulating trans-zeatin-type cytokinin levels in xylem.Plant & cell physiology · 2026Article
- Evolutionary Repurposing of Cytokinin Signaling in Plant Development and Symbiosis.Plants (Basel, Switzerland) · 2026Review
- The SlDOF3.4-SlCDF4 module improves tomato growth under low-nitrogen conditions.Horticulture research · 2026Article
- Nitrogen-Controlled Host Gatekeeping: Regulatory Chokepoints Across Four Windows for Diazotroph Access.International journal of molecular sciences · 2026Article
- Symbiosome membrane-localized cationic amino acid transporters support symbiotic nitrogen fixation in Medicago truncatula.Plant communications · 2026Article
- Moderate organic-inorganic fertilization optimizes soybean productivity by reshaping rhizosphere microbiome-metabolite networks.Frontiers in plant science · 2026Article
- Nodule-specificaBIOTECH · 2025Article
- Article
- Elemental and isotopic analysis of leaves predicts nitrogen-fixing phenotypes.Scientific reports · 2024Article
- Article
- Nitrogen and Nod factor signaling determine Lotus japonicus root exudate composition and bacterial assembly.Nature communications · 2024Article
- Metal nutrition and transport in the process of symbiotic nitrogen fixation.Plant communications · 2024Review
- Staying hungry: a roadmap to harnessing central regulators of symbiotic nitrogen fixation under fluctuating nitrogen availability.aBIOTECH · 2024Article
- Analysis of the beneficial effects of prior soybean cultivation to the field on corn yield and soil nitrogen content.Frontiers in plant science · 2024Article
- Symbiotic Functioning and Photosynthetic Rates Induced by Rhizobia Associated with Jack Bean (Microorganisms · 2023Article
- The NAC transcription factors SNAP1/2/3/4 are central regulators mediating high nitrogen responses in mature nodules of soybean.Nature communications · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Legumes balance nitrogen acquisition from soil nitrate with symbiotic nitrogen fixation. Nitrogen fixation requires establishment of a new organ, which is a cytokinin dependent developmental process in the root. We found cytokinin biosynthesis is a central integrator, balancing nitrate signalling with symbiotic acquired nitrogen. Low nitrate conditions provide a permissive state for induction of cytokinin by symbiotic signalling and thus nodule development. In contrast, high nitrate is inhibitory to cytokinin accumulation and nodule establishment in the root zone susceptible to nodule formation. This reduction of symbiotic cytokinin accumulation was further exacerbated in cytokinin biosynthesis mutants, which display hypersensitivity to nitrate inhibition of nodule development, maturation and nitrogen fixation. Consistent with this, cytokinin application rescues nodulation and nitrogen fixation of biosynthesis mutants in a concentration dependent manner. These inhibitory impacts of nitrate on symbiosis occur in a Nlp1 and Nlp4 dependent manner and contrast with the positive influence of nitrate on cytokinin biosynthesis that occurs in species that do not form symbiotic root nodules. Altogether this shows that legumes, as exemplified by Lotus japonicus, have evolved a different cytokinin response to nitrate compared to non-legumes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.