ArticleNeurology(R) neuroimmunology & neuroinflammation2022
Analysis of Macrophages and Peptidergic Fibers in the Skin of Patients With Painful Diabetic Polyneuropathy.
Erratum issuedOpen access · goldAbstract read
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Article in Neurology(R) neuroimmunology & neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 1 of them a synthesis that pooled it.
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27citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
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27 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Is acupoint injection the optimal way to administer mecobalamin for diabetic peripheral neuropathy? A meta-analysis and trial sequential analysis.Frontiers in neurology · 2023Pooled it
- TrkA abundance is increased in cutaneous nerves in bortezomib-induced neuropathy.Brain pathology (Zurich, Switzerland) · 2026Article
- Skin-resident Langerhans cells drive neuropathic pain via chemokine-dependent neuron-immune communication.The Journal of clinical investigation · 2026Article
- Dermal fibroblast mitochondrial profiles in painful diabetic neuropathy.Diabetologia · 2026Article
- Cellular and molecular basis of neuropathic pain.RMD open · 2026Review
- Piezo1 in neuropathic pain: a putative mechanotransduction hub and underlying mechanisms.Frontiers in molecular neuroscience · 2026Review
- Multidimensional Regulatory Mechanisms and Targeted Therapeutic Strategies for Inhibited Keratinocyte Proliferation in Diabetic Wounds.Drug design, development and therapy · 2026Review
- Preservation of Nociceptor Intraepidermal Nerve Fibres in Diabetic Neuropathic Pain.Journal of diabetes research · 2026Article
- A pilot imaging mass cytometry study of cutaneous nerve-immune cell interactions in post-herpetic neuralgia.Frontiers in immunology · 2026Article
- Trigeminal nerve root compression induced neuroinflammatory response promotes mechanical allodynia through the CGRP/SP-Piezo2 axis via CaCellular & molecular biology letters · 2025Article
- TLR4 deletion reduces small fiber sensory abnormalities and nerve degeneration in diabetic male mice.Neuroscience · 2025Article
- Macrophage polarization in diabetic vascular complications: mechanistic insights and therapeutic targets.Journal of translational medicine · 2025Review
- A role for fibroblast and mural cell subsets in a nerve ligation model of neuropathic pain?Brain, behavior, and immunity · 2025Article
- Article
- The Effect of Fremanezumab on Pain in Patients with Complex Regional Pain Syndrome: Study Protocol of a Randomized, Double-Blind, Proof-of-Concept, Placebo-Controlled Trial.Brain sciences · 2025Article
- Hypertension is associated with the reduction in epidermal small fibres independently of sural nerve inflammation in type 2 diabetic subjects.Journal of neurochemistry · 2025Article
- Diabetic Peripheral Neuropathy: Pathophysiology and New Insights into the Mechanism of Action of High-Concentration Topical Capsaicin.Journal of experimental pharmacology · 2025Review
- The role of novel inflammation-associated biomarkers in diabetic peripheral neuropathy.Metabolism open · 2024Review
- Injectable, reversibly thermoresponsive captopril-laden hydrogel for the local treatment of sensory loss in diabetic neuropathy.Scientific reports · 2024Article
- Post-COVID Small Fiber Neuropathy, Implications of Innate Immunity, and Challenges on IVIG Therapy.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 1 institution in 1 country.
Sandra Sif GylfadottirFrom the Danish Pain Research Center (S.S.G., T.S.J., N.B.F., P.K.), Department of Clinical Medicine, Aarhus University; Research Unit for Neurology (M.I., S.H.S.), Odense University Hospital, Odense, Denmark, University of Southern Denmark, Odense; Department of Clinical Neurophysiology (A.G.K., H.T.), Aarhus University Hospital; Department of Neurology (S.S.G., T.S.J., N.B.F.), Aarhus University Hospital, Denmark; Nuffield Department of Clinical Neurosciences (D.B.), University of Oxford, United Kingdom; Core Center for Molecular Morphology (J.R.N., P.K.), Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University; and Department of Pathology (J.R.N.), Aarhus University Hospital, Denmark.ORCID 0000-0003-0411-4403
Mustapha ItaniFrom the Danish Pain Research Center (S.S.G., T.S.J., N.B.F., P.K.), Department of Clinical Medicine, Aarhus University; Research Unit for Neurology (M.I., S.H.S.), Odense University Hospital, Odense, Denmark, University of Southern Denmark, Odense; Department of Clinical Neurophysiology (A.G.K., H.T.), Aarhus University Hospital; Department of Neurology (S.S.G., T.S.J., N.B.F.), Aarhus University Hospital, Denmark; Nuffield Department of Clinical Neurosciences (D.B.), University of Oxford, United Kingdom; Core Center for Molecular Morphology (J.R.N., P.K.), Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University; and Department of Pathology (J.R.N.), Aarhus University Hospital, Denmark.
Alexander Gramm KristensenFrom the Danish Pain Research Center (S.S.G., T.S.J., N.B.F., P.K.), Department of Clinical Medicine, Aarhus University; Research Unit for Neurology (M.I., S.H.S.), Odense University Hospital, Odense, Denmark, University of Southern Denmark, Odense; Department of Clinical Neurophysiology (A.G.K., H.T.), Aarhus University Hospital; Department of Neurology (S.S.G., T.S.J., N.B.F.), Aarhus University Hospital, Denmark; Nuffield Department of Clinical Neurosciences (D.B.), University of Oxford, United Kingdom; Core Center for Molecular Morphology (J.R.N., P.K.), Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University; and Department of Pathology (J.R.N.), Aarhus University Hospital, Denmark.ORCID 0000-0001-9658-4108
Hatice TankisiFrom the Danish Pain Research Center (S.S.G., T.S.J., N.B.F., P.K.), Department of Clinical Medicine, Aarhus University; Research Unit for Neurology (M.I., S.H.S.), Odense University Hospital, Odense, Denmark, University of Southern Denmark, Odense; Department of Clinical Neurophysiology (A.G.K., H.T.), Aarhus University Hospital; Department of Neurology (S.S.G., T.S.J., N.B.F.), Aarhus University Hospital, Denmark; Nuffield Department of Clinical Neurosciences (D.B.), University of Oxford, United Kingdom; Core Center for Molecular Morphology (J.R.N., P.K.), Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University; and Department of Pathology (J.R.N.), Aarhus University Hospital, Denmark.
Troels Staehelin JensenFrom the Danish Pain Research Center (S.S.G., T.S.J., N.B.F., P.K.), Department of Clinical Medicine, Aarhus University; Research Unit for Neurology (M.I., S.H.S.), Odense University Hospital, Odense, Denmark, University of Southern Denmark, Odense; Department of Clinical Neurophysiology (A.G.K., H.T.), Aarhus University Hospital; Department of Neurology (S.S.G., T.S.J., N.B.F.), Aarhus University Hospital, Denmark; Nuffield Department of Clinical Neurosciences (D.B.), University of Oxford, United Kingdom; Core Center for Molecular Morphology (J.R.N., P.K.), Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University; and Department of Pathology (J.R.N.), Aarhus University Hospital, Denmark.
Søren H SindrupFrom the Danish Pain Research Center (S.S.G., T.S.J., N.B.F., P.K.), Department of Clinical Medicine, Aarhus University; Research Unit for Neurology (M.I., S.H.S.), Odense University Hospital, Odense, Denmark, University of Southern Denmark, Odense; Department of Clinical Neurophysiology (A.G.K., H.T.), Aarhus University Hospital; Department of Neurology (S.S.G., T.S.J., N.B.F.), Aarhus University Hospital, Denmark; Nuffield Department of Clinical Neurosciences (D.B.), University of Oxford, United Kingdom; Core Center for Molecular Morphology (J.R.N., P.K.), Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University; and Department of Pathology (J.R.N.), Aarhus University Hospital, Denmark.
David LH BennettFrom the Danish Pain Research Center (S.S.G., T.S.J., N.B.F., P.K.), Department of Clinical Medicine, Aarhus University; Research Unit for Neurology (M.I., S.H.S.), Odense University Hospital, Odense, Denmark, University of Southern Denmark, Odense; Department of Clinical Neurophysiology (A.G.K., H.T.), Aarhus University Hospital; Department of Neurology (S.S.G., T.S.J., N.B.F.), Aarhus University Hospital, Denmark; Nuffield Department of Clinical Neurosciences (D.B.), University of Oxford, United Kingdom; Core Center for Molecular Morphology (J.R.N., P.K.), Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University; and Department of Pathology (J.R.N.), Aarhus University Hospital, Denmark.
Jens Randel NyengaardFrom the Danish Pain Research Center (S.S.G., T.S.J., N.B.F., P.K.), Department of Clinical Medicine, Aarhus University; Research Unit for Neurology (M.I., S.H.S.), Odense University Hospital, Odense, Denmark, University of Southern Denmark, Odense; Department of Clinical Neurophysiology (A.G.K., H.T.), Aarhus University Hospital; Department of Neurology (S.S.G., T.S.J., N.B.F.), Aarhus University Hospital, Denmark; Nuffield Department of Clinical Neurosciences (D.B.), University of Oxford, United Kingdom; Core Center for Molecular Morphology (J.R.N., P.K.), Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University; and Department of Pathology (J.R.N.), Aarhus University Hospital, Denmark.
Nanna Brix FinnerupFrom the Danish Pain Research Center (S.S.G., T.S.J., N.B.F., P.K.), Department of Clinical Medicine, Aarhus University; Research Unit for Neurology (M.I., S.H.S.), Odense University Hospital, Odense, Denmark, University of Southern Denmark, Odense; Department of Clinical Neurophysiology (A.G.K., H.T.), Aarhus University Hospital; Department of Neurology (S.S.G., T.S.J., N.B.F.), Aarhus University Hospital, Denmark; Nuffield Department of Clinical Neurosciences (D.B.), University of Oxford, United Kingdom; Core Center for Molecular Morphology (J.R.N., P.K.), Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University; and Department of Pathology (J.R.N.), Aarhus University Hospital, Denmark.
Pall KarlssonFrom the Danish Pain Research Center (S.S.G., T.S.J., N.B.F., P.K.), Department of Clinical Medicine, Aarhus University; Research Unit for Neurology (M.I., S.H.S.), Odense University Hospital, Odense, Denmark, University of Southern Denmark, Odense; Department of Clinical Neurophysiology (A.G.K., H.T.), Aarhus University Hospital; Department of Neurology (S.S.G., T.S.J., N.B.F.), Aarhus University Hospital, Denmark; Nuffield Department of Clinical Neurosciences (D.B.), University of Oxford, United Kingdom; Core Center for Molecular Morphology (J.R.N., P.K.), Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University; and Department of Pathology (J.R.N.), Aarhus University Hospital, Denmark. pall@clin.au.dk.ORCID 0000-0001-7082-9576
University of Southern Denmark · DK
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe mechanisms of pain in patients with diabetic polyneuropathy are unknown. Studies have suggested a role of inflammation and increased neuropeptides peripherally in pain generation. This study examined the possible skin markers of painful diabetic polyneuropathy (P-DPN): macrophages, substance P (SP), and calcitonin gene-related peptide (CGRP).
methodsThe participants were included from a large Danish cross-sectional clinical study of type 2 diabetes. We diagnosed definite diabetic polyneuropathy using the Toronto criteria and used the Neuropathic Pain Special Interest Group classification for defining P-DPN. We included 60 skin biopsies from patients with diabetic polyneuropathy-30 with P-DPN and 30 with nonpainful diabetic polyneuropathy (NP-DPN)-and 30 biopsies from healthy controls of similar age and sex. The biopsies were stained using PGP 9.5, IbA1, and SP and CGRP primary markers.
resultsThere was increased macrophage density in patients with P-DPN (8.0%) compared with that in patients with NP-DPN (5.1%, DISCUSSION: The findings point to a possible involvement of the innate immune system in the pathogenesis of neuropathic pain in patients with DPN, although markers of activated macrophages were not measured in this study.
Indexed as
Diabetic NeuropathiesMacrophagesNerve FibersNeuralgiaSkinAgedBiomarkersBiopsyCalcitonin Gene-Related PeptideCross-Sectional StudiesFemaleHumansMaleMiddle AgedSubstance PBiomarkersCalcitonin Gene-Related PeptideSubstance P
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