ArticleJournal of neurology, neurosurgery, and psychiatry2022
Retinal inter-eye difference and atrophy progression in multiple sclerosis diagnostics.
Article in Journal of neurology, neurosurgery, and psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Retinal optical coherence tomography measures in multiple sclerosis: a systematic review and meta-analysis.Annals of clinical and translational neurology · 2024Pooled it
- Fifteen-Year Longitudinal Changes in Peripapillary Retinal Nerve Fiber Layer Thickness in Multiple Sclerosis.Journal of clinical medicine · 2026Article
- Assessing the Validity of the Fellow Eye as an Internal Control in Early-Phase Clinical Trials for Myopic Chorioretinal Atrophy.Journal of clinical medicine · 2026Article
- Assessing Optic Nerve Involvement in Multiple Sclerosis Using Optical Coherence Tomography and Magnetic Resonance Imaging.European journal of neurology · 2026Article
- Application of optical coherence tomography in multiple sclerosis: consensus recommendations of the Austrian network (AN-OCT-MS).Journal of neurology · 2025Article
- New Method of Early RRMS Diagnosis Using OCT-Assessed Structural Retinal Data and Explainable Artificial Intelligence.Translational vision science & technology · 2025Article
- FundusNet: A Deep-Learning Approach for Fast Diagnosis of Neurodegenerative and Eye Diseases Using Fundus Images.Bioengineering (Basel, Switzerland) · 2025Article
- Interocular symmetry and asymmetry in ocular health and disease.Frontiers in medicine · 2025Review
- Diagnostic Value of Inter-Eye Difference Metrics on OCT for Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- Diagnosis of multiple sclerosis using optical coherence tomography supported by explainable artificial intelligence.Eye (London, England) · 2024Article
- Article
- Delimiting MOGAD as a disease entity using translational imaging.Frontiers in neurology · 2023Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe visual system could be included in the diagnostic criteria for multiple sclerosis (MS) to demonstrate dissemination in space (DIS) and dissemination in time (DIT).
objectiveTo investigate the diagnostic value of retinal asymmetry in MS.
methodsA prospective, longitudinal study in individuals with MS (n=151) and healthy controls (n=27). Optical coherence tomography (OCT) was performed at 0, 2 and 4 years. Macular ganglion cell and inner plexiform layer (mGCIPL) thickness was determined as well as measures for retinal asymmetry: the inter-eye percentage difference (IEPD) and inter-eye absolute difference (IEAD). Receiver operator characteristics curves were plotted and the area under the curve (AUC) was calculated for group comparisons of the mGCIPL, IEPD, IEAD and atrophy rates.
resultsThe diagnostic accuracy of both the IEPD and IEAD for differentiating bilateral and unilateral MS optic neuritis was high and stable over time (AUCs 0.88-0.93). The IEPD slightly outperformed the IEAD. Atrophy rates showed low discriminatory abilities for differentiating MS from controls (AUC 0.49-0.58).
conclusionThe inter-eye differences of the mGCIPL have value for demonstration of DIS but in individuals with longstanding MS not for DIT. This may be considered as a test to detect DIS in future diagnostic criteria. Validation in a large prospective study in people presenting with symptoms suggestive of MS is required.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.