Evidence map›Paper›PMID 34764141›Full record

ReviewBMJ open gastroenterology2021

Enteropathies with villous atrophy but negative coeliac serology in adults: current issues.

Annalisa Schiepatti, Marta Cincotta, Federico Biagi, David S Sanders

Open access · goldAbstract readReview
In one paragraph

Review in BMJ open gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. A laboratory test to detect gliadin-specific CD4Journal of translational autoimmunity · 2025
    Article
  4. Review
  5. Celiac Disease: Beyond Diet and Food Awareness.Foods (Basel, Switzerland) · 2025
    Review
  6. Review
  7. Small Bowel Villous Atrophy in a Young Patient: A Challenging Diagnosis.GE Portuguese journal of gastroenterology · 2024
    Article
  8. Review
  9. Unusual Cause of Duodenal Villi Atrophy.Digestive diseases and sciences · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Annalisa SchiepattiGastroenterology Unit of Pavia Institute, Maugeri Clinical Research Institutes IRCCS, University of Pavia, Pavia, Italy.ORCID 0000-0002-8493-7698
Marta CincottaGastroenterology Unit of Pavia Institute, Maugeri Clinical Research Institutes IRCCS, University of Pavia, Pavia, Italy.
Federico BiagiGastroenterology Unit of Pavia Institute, Maugeri Clinical Research Institutes IRCCS, University of Pavia, Pavia, Italy.
David S SandersAcademic Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, United Kigdom david.sanders1@nhs.net.ORCID 0000-0002-3739-0124
University of Pavia · ITRoyal Hallamshire Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe differential diagnosis and management of seronegative enteropathies is challenging due to the rarity of these conditions, the overlap of clinical and histopathological features and the current lack of an international consensus on their nomenclature.

designThis is a narrative review providing pragmatic guide on the investigation and clinical management of seronegative enteropathies in adults based on the available literature and our clinical experience.

conclusionsSeronegative coeliac disease is the most frequent cause among the heterogeneous group of seronegative enteropathies and its diagnosis is confirmed by the clinical and histological response to a gluten-free diet after the exclusion of other causes of villous atrophy. Correct identification and targeted management of seronegative enteropathies is mandatory because of the variation in terms of clinical outcomes and prognosis.

Indexed as

Celiac DiseaseIntestinal DiseasesAdultAtrophyDiet, Gluten-FreeHumansIntestinal Mucosaceliac diseasegluten free dietmalabsorptionsmall intestinal biopsy

Identifiers

PMID34764141
PMCPMC8587352
OpenAlexW3212150124

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.