Evidence map›Paper›PMID 34764108›Full record

ArticleBMJ case reports2021

Gemtuzumab-ozogamicin and blinatumomab as treatment for refractory mixed-phenotype blast crisis in chronic myeloid leukaemia.

Roberto Ovilla-Martinez, Luis Alejandro Weber Sánchez, Xóchitl Cota-Rangel, Pamela Elena Baez-Islas

Open access · greenAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Roberto Ovilla-MartinezHematology Department, Hospital Angeles Lomas, Huixquilucan, Estado de Mexico, Mexico.
Luis Alejandro Weber SánchezHematology Department, Hospital Angeles Lomas, Huixquilucan, Estado de Mexico, Mexico.
Xóchitl Cota-RangelHematology Department, Hospital Angeles Lomas, Huixquilucan, Estado de Mexico, Mexico.
Pamela Elena Baez-IslasHematology Department, Hospital Angeles Lomas, Huixquilucan, Estado de Mexico, Mexico drabaez.hematologia@gmail.com.ORCID http://orcid.org/0000-0003-2338-9437

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the tyrosine kinase inhibitor era, the blast phase of chronic myeloid leukaemia (BP-CML) renders an uncommon presentation and has a poor prognosis with an estimated overall survival below 20%. Mixed-phenotype blast phase is even more infrequent, presenting in 3.3% of these patients. Blast phase manifests along haematological sarcomas, with extramedullary activity in lymph nodes, skin and bone. We report the case of a patient with an ovarian sarcoma as an extramedullary presentation of mixed-phenotype BP-CML refractory to conventional treatment which responded to immunotherapy against CD33 and CD19.

Indexed as

Blast CrisisLeukemia, Myelogenous, Chronic, BCR-ABL PositiveAntibodies, BispecificGemtuzumabHumansPhenotypeAntibodies, BispecificblinatumomabGemtuzumabcancer - see oncologychronic myeloid leukaemiahaematology (drugs and medicines)haematology (incl blood transfusion)

Identifiers

PMID34764108
PMCPMC8586884
OpenAlexW3212021268

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.