Evidence map›Paper›PMID 34764084›Full record

ArticleAJNR. American journal of neuroradiology2022

Quantifying T2-FLAIR Mismatch Using Geographically Weighted Regression and Predicting Molecular Status in Lower-Grade Gliomas.

S Mohammed, V Ravikumar, E Warner, S H Patel, S Bakas, A Rao, R Jain

Open access · hybridAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

S MohammedFrom the Departments of Biostatistics (S.M., A.R.) ukarvind@umich.edu.ORCID 0000-0002-3107-2969
V RavikumarComputational Medicine & Bioinformatics (S.M., V.R., E.W., A.R.).ORCID 0000-0003-4670-3898
E WarnerComputational Medicine & Bioinformatics (S.M., V.R., E.W., A.R.).ORCID 0000-0001-6694-2701
S H PatelDepartment of Radiology & Medical Imaging (S.H.P.), University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0002-9739-4362
S BakasDepartments of Radiology (S.B.).ORCID 0000-0001-8734-6482
A RaoFrom the Departments of Biostatistics (S.M., A.R.) ukarvind@umich.edu.ORCID 0000-0002-9613-426X
R JainDepartments of Radiology (R.J.).ORCID 0000-0002-4879-0457
Bioinformatics Institute · RUResearch Institute of Radiology · BYFord Motor Company (United States) · USMRC Biostatistics Unit · GBUniversity of Virginia Medical Center · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Statistical atlases of brain tumor MRI:do imaging phenotypes predict progression?R01NS042645 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2002 to 2024
$8.7M
Synthesizing Image-derived Heterogeneity with Genomic measurements for Assessing Disease Aggressiveness in Lower Grade GliomasR37CA214955 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KURTEK, SEBASTIAN, RAO, ARVIND · 2018 to 2024
$3.9M
Cancer imaging phenomics software suite: application to brain and breast cancerU24CA189523 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS, KONTOS, DESPINA · 2015 to 2019
$3.2M
Biomedical Image Computing and Informatics ClusterS10OD023495 · OD · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2017
$1.9M
The Federated Tumor Segmentation (FeTS) platform: An intuitive tool facilitating secure multi-institutional collaborationU01CA242871 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BAKAS, SPYRIDON · 2019 to 2021
$1.1M
NCI NIH HHS P30 CA046592NCI NIH HHS R37 CA214955NCI NIH HHS U01 CA242871NCI NIH HHS U24 CA189523NIH HHS S10 OD023495NINDS NIH HHS R01 NS042645
6 · The paper itself

Abstract

background and purposeThe T2-FLAIR mismatch sign is a validated imaging sign of MATERIALS AND

methodsWe used multiparametric MR imaging scans and segmentation labels of 108 preoperative lower-grade glioma tumors from The Cancer Imaging Archive. Clinical information and T2-FLAIR mismatch sign labels were obtained from supplementary material of relevant publications. We adopted an objective analytic approach to estimate this sign through a geographically weighted regression and used the residuals for each case to construct a probability density function (serving as a residual signature). These functions were then analyzed using an appropriate statistical framework.

resultsWe observed statistically significant (

conclusionsOn the basis of this retrospective study, we show that geographically weighted regression-based residual signatures are highly informative of the T2-FLAIR mismatch sign and can identify

Indexed as

Brain NeoplasmsGliomaHumansIsocitrate DehydrogenaseMagnetic Resonance ImagingMutationProspective StudiesRetrospective StudiesSpatial RegressionIsocitrate Dehydrogenase

Identifiers

PMID34764084
PMCPMC8757555
OpenAlexW3211584756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.