Evidence map›Paper›PMID 34763220›Full record

SynthesisJournal of anxiety disorders2021

Efficacy and acceptability of interventions for co-occurring PTSD and SUD: A meta-analysis.

Tracy L Simpson, Simon B Goldberg, Diana K N Louden, Shannon M Blakey, Sage E Hawn, Aline Lott, Kendall C Browne, Keren Lehavot, Debra Kaysen

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of anxiety disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  17. MDMA alters fear extinction, and reduces alcohol consumption in inbred alcohol preferring iP rats but not outbred Wistar rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tracy L SimpsonVA Puget Sound Center of Excellence in Substance Addiction Treatment and Education, 1660 South Columbian Way, Seattle, WA 98108, USA; University of Washington, Department of Psychiatry, 1959 NE Pacific St, Seattle, WA 98195, USA. Electronic address: Tracy.Simpson@va.gov.
Simon B GoldbergDepartment of Counseling Psychology, University of Wisconsin - Madison, 1000 Bascom Mall, Madison, WI 53706, USA. Electronic address: sbgoldberg@wisc.edu.
Diana K N LoudenUniversity of Washington, Health Sciences Libraries, 1959 NE Pacific St, Seattle, WA 98195, USA. Electronic address: dknl@uw.edu.
Shannon M BlakeyDurham VA Medical Center, 508 Fulton St, Durham, NC 27705, USA; VA Mid-Atlantic Mental Illness Research, Education and Clinical Center, 3022 Croasdaile Dr, Durham, NC 27705, USA. Electronic address: Shannon.Blakey@va.gov.
Sage E HawnBoston VA Medical Center, 150S Huntington Ave, Boston, MA 02130, USA. Electronic address: Sage.Hawn@va.gov.
Aline LottVA Puget Sound Center of Excellence in Substance Addiction Treatment and Education, 1660 South Columbian Way, Seattle, WA 98108, USA. Electronic address: Aline.Lott@va.gov.
Kendall C BrowneVA Puget Sound Center of Excellence in Substance Addiction Treatment and Education, 1660 South Columbian Way, Seattle, WA 98108, USA; University of Washington, Department of Psychiatry, 1959 NE Pacific St, Seattle, WA 98195, USA. Electronic address: Kendall.Browne@va.gov.
Keren LehavotUniversity of Washington, Department of Psychiatry, 1959 NE Pacific St, Seattle, WA 98195, USA; VA Puget Sound Seattle/Denver HSR&D COIN, 1660 South Columbian Way, Seattle, WA 98108, USA. Electronic address: Keren.Lehavot@va.gov.
Debra KaysenStanford University, Department of Psychiatry, 401 Quarry Road, Stanford, CA 94305, USA. Electronic address: dkaysen@stanford.edu.

Funding

Mindfulness training delivered via mobile health to reduce depression and anxietyK23AT010879 · NCCIH · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDBERG, SIMON B · 2020 to 2024
$786k
NCCIH NIH HHS K23 AT010879
6 · The paper itself

Abstract

Over the past 20 years, numerous treatments addressing comorbid Posttraumatic Stress Disorder (PTSD) and Substance Use Disorder (SUD) have been developed and tested. The current meta-analysis examined the efficacy and acceptability of the two central treatment types- trauma-focused and non-trauma-focused - compared with all comparators and with cognitive-behavioral manualized SUD treatments immediately post-treatment and at longest follow-up. Twenty-eight randomized clinical trials (N = 3247) were included. There were small to large within-group effects for all forms of active treatment (gs = 0.30-1.11). Trauma-focused but not non-trauma-focused treatments outperformed all comparators on PTSD outcomes at post-treatment. Neither trauma-focused nor non-trauma-focused treatment outperformed all comparators on SUD outcomes at post-treatment. Neither trauma- nor non-trauma-focused treatment outperformed manualized SUD treatments on PTSD outcomes at either time point. Manualized SUD treatments outperformed trauma-focused treatments on SUD outcomes at post-treatment and non-trauma-focused treatments on PTSD outcomes at follow-up. Regarding treatment retention, neither trauma-focused nor non-trauma-focused treatments significantly differed from all comparators or from manualized SUD treatments. Between-group results were largely unchanged in trim-and-fill analyses, but were not robust to fail-safe N. Few moderators were detected. Taken together, results suggest that trauma-focused, non-trauma-focused, and manualized SUD interventions are sound options for individuals with comorbid PTSD/SUD.

Indexed as

Cognitive Behavioral TherapyStress Disorders, Post-TraumaticSubstance-Related DisordersComorbidityHumansCognitive behavior therapyMeta analysisPosttraumatic stress disorderRandomized controlled trialsSubstance use disorder

Identifiers

PMID34763220
PMCPMC8819868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.