Evidence map›Paper›PMID 34763081›Full record

ArticleBioorganic & medicinal chemistry letters2021

Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase.

Simon D P Baugh, Michael R Jackson, Adel Ahmed Rashad, Allen B Reitz, Patrick Y S Lam, Marilyn Schuman Jorns

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. SQOR as a metabolic rheostat of HFrontiers in cell and developmental biology · 2025
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Simon D P BaughFox Chase Chemical Diversity Center, Inc., Doylestown, PA 18902, USA.
Michael R JacksonDepartment of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
Adel Ahmed RashadDepartment of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
Allen B ReitzFox Chase Chemical Diversity Center, Inc., Doylestown, PA 18902, USA.
Patrick Y S LamFox Chase Chemical Diversity Center, Inc., Doylestown, PA 18902, USA.
Marilyn Schuman JornsDepartment of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA. Electronic address: mj27@drexel.edu.

Funding

Inhibitors of Hydrogen Sulfide Metabolism as a Novel Treatment for Heart FailureR41HL134435 · NHLBI · FOX CHASE CHEMICAL DIVERSITY CENTER, INC · PI JORNS, MARILYN S · 2017 to 2017
$300k
NHLBI NIH HHS R41 HL134435
6 · The paper itself

Abstract

Here we report the first small-molecule inhibitors of human sulfide:quinone oxidoreductase (SQOR) that decrease the rate of breakdown of hydrogen sulfide (H

Indexed as

Dose-Response Relationship, DrugEnzyme InhibitorsHumansHydrocarbons, AromaticMolecular StructureOxidoreductases Acting on Sulfur Group DonorsSmall Molecule LibrariesStructure-Activity RelationshipEnzyme InhibitorsHydrocarbons, AromaticOxidoreductases Acting on Sulfur Group DonorsSmall Molecule LibrariesSQOR protein, humanHeart failureSAR developmentSmall-molecule inhibitorsSulfide:quinone oxidoreductase (SQOR)

Identifiers

PMID34763081
PMCPMC8670630

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.