Evidence map›Paper›PMID 34763080›Full record

Trial reportJournal of cardiac failure2022

Randomized Controlled Trial of a Cognitive Intervention to Improve Memory in Heart Failure.

Susan J Pressler, Miyeon Jung, Irmina Gradus-Pizlo, Marita G Titler, Dean G Smith, Sujuan Gao, Kittie Reid Lake, Heather Burney, David G Clark, Kelly L Wierenga and 2 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cardiac failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03035565 (Cognitive Intervention to Improve Memory in Heart Failure Patients), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03035565 nacompletednot on this map

Cognitive Intervention to Improve Memory in Heart Failure Patients

TypeinterventionalSponsorIndiana UniversityRan2017 to 2021Enrolled276ConditionsHeart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure NYHA Class IArmsComputerized Cognitive Training with Brain HQ, Computerized Crossword Puzzles
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Susan J PresslerIndiana University School of Nursing, 600 Barnhill Drive, Indianapolis, Indiana. Electronic address: sjpress@iu.edu.
Miyeon JungIndiana University School of Nursing, 600 Barnhill Drive, Indianapolis, Indiana.
Irmina Gradus-PizloUniversity of California Irvine School of Medicine, 333 City Boulevard, West, Suite 400, Orange, California.
Marita G TitlerUniversity of Michigan School of Nursing, 400 North Ingalls Street, Ann Arbor, Michigan.
Dean G SmithLouisiana State University School of Public Health, 2020 Gravier Street, 3rd Floor, New Orleans, Louisiana.
Sujuan GaoIndiana University School of Medicine, Department of Biostatistics, 410 West 10th Street, Suite 3000, Indianapolis, Indiana.
Kittie Reid LakeIndiana University School of Nursing, 600 Barnhill Drive, Indianapolis, Indiana.
Heather BurneyIndiana University School of Medicine, Department of Biostatistics, 410 West 10th Street, Suite 3000, Indianapolis, Indiana.
David G ClarkIndiana University School of Medicine, 355 W. 16th Street, Suite 4020, Indianapolis, Indiana.
Kelly L WierengaIndiana University School of Nursing, 600 Barnhill Drive, Indianapolis, Indiana.
Susan G DorseyUniversity of Maryland School of Nursing, 655 West Lombard Street, Baltimore, Maryland.
Bruno GiordaniUniversity of Michigan Department of Psychiatry and Michigan's Alzheimer's Disease Research Center, Suite C, 2101 Commonwealth Boulevard, Ann Arbor, Michigan.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineUniversity of Michigan–Ann Arbor · USLouisiana State University Health Sciences Center New Orleans · USUniversity of California, Irvine · USUniversity of Maryland, Baltimore · US

Funding

Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
Cognitive Intervention to Improve Memory in Heart Failure PatientsR01NR016116 · NINR · INDIANA UNIVERSITY INDIANAPOLIS · PI GIORDANI, BRUNO, PRESSLER, SUSAN JANE · 2016 to 2020
$2.9M
NIDDK NIH HHS P30 DK097512NINR NIH HHS R01 NR016116
6 · The paper itself

Abstract

backgroundThe objective of this 3-arm randomized controlled trial was to evaluate the efficacy of computerized cognitive training (CCT) in improving primary outcomes of delayed-recall memory and serum brain-derived neurotrophic factor (BDNF) levels; and the secondary outcomes were working memory, instrumental activities of daily living (IADLs) and health-related quality of life (HRQL) in patients with heart failure (HF). METHODS AND

resultsPatients (n = 256) were randomly assigned to 8 weeks of CCT using BrainHQ, computerized crossword puzzles active control intervention, and usual care. All patients received weekly nurse-enhancement interventions. Data were collected at enrollment and baseline visits and at 10 weeks and 4 and 8 months. In mixed effects models, there were no statistically significant group or group-by-time differences in outcomes. There were statistically significant differences over time in all outcomes in all groups. Patients improved over time on measures of delayed-recall memory, working memory, IADLs, and HRQL and had decreased serum BDNF.

conclusionsCCT did not improve outcomes compared with the active control intervention and usual care. Nurse-enhancement interventions may have led to improved outcomes over time. Future studies are needed to test nurse-enhancement interventions in combination with other cognitive interventions to improve memory in persons with HF.

Indexed as

Brain-Derived Neurotrophic FactorHeart FailureActivities of Daily LivingCognitionHumansQuality of LifeBrain-Derived Neurotrophic Factorcognitive dysfunctioncomputerized cognitive trainingheart failurenurse-enhancement intervention

Identifiers

PMID34763080
PMCPMC9018491
OpenAlexW3213487733

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.