Evidence map›Paper›PMID 34763021›Full record

ReviewJournal of neuroscience methods2022

Current and future techniques for detecting oxytocin: Focusing on genetically-encoded GPCR sensors.

Dongmin Lee, Hyung-Bae Kwon

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neuroscience methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dongmin LeeDepartment of Anatomy, Korea University College of Medicine, Seoul, Republic of Korea; BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea.
Hyung-Bae KwonSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 733N Broadway, Baltimore, MD 21205, USA. Electronic address: hkwon29@jhmi.edu.

Funding

Cracking the neuromodulation code at single cell resolutionDP1MH119428 · NIMH · MAX PLANCK FLORIDA CORPORATION · PI KWON, HYUNGBAE · 2018 to 2022
$5.9M
NIMH NIH HHS DP1 MH119428
6 · The paper itself

Abstract

Oxytocin is a neuropituitary hormone that is involved in a wide range of psychosocial behaviors. Despite its psychophysiological importance as a neuromodulator in the CNS, effective techniques capable of monitoring oxytocin dynamics or testing related behavioral consequences are limited. Along with an explosive advancement in synthetic biology, high-performance genetically-encoded neuromodulator sensors are being developed. Here we comprehensively review the current methodologies available for detecting oxytocin in neuroscience. Their strengths and weaknesses are discussed, and a graphical summary is plotted for better comparison of techniques. We also suggest future directions for next generation oxytocin sensor development and their working principles.

Indexed as

Biosensing TechniquesOxytocinReceptors, G-Protein-CoupledOxytocinReceptors, G-Protein-CoupledArrestinCircularly permuted fluorescent proteinEnzyme complementationFast-scan cyclic voltammetryGene expressionGenetically encoded sensorG protein-coupled receptorMicrodialysisNeuromodulatorNeuropeptideOxytocinSplit luciferaseTEV protease

Identifiers

PMID34763021
PMCPMC11877391

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.