Evidence map›Paper›PMID 34762911›Full record

ArticleThe Journal of biological chemistry2021

Hepatocyte-specific perturbation of NAD

Morten Dall, Anna S Hassing, Lili Niu, Thomas S Nielsen, Lars R Ingerslev, Karolina Sulek, Samuel A J Trammell, Matthew P Gillum, Romain Barrès, Steen Larsen and 4 more

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Expression of CD38Scientific reports · 2026
    Article
  5. NADNature metabolism · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Nicotinamide Riboside, a Promising Vitamin BMolecules (Basel, Switzerland) · 2023
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Balancing NADCellular and molecular life sciences : CMLS · 2022
    Review
  18. NADMetabolites · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 3 countries.

Morten DallNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Anna S HassingNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Lili NiuNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Thomas S NielsenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Lars R IngerslevNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Karolina SulekNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Samuel A J TrammellNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Matthew P GillumNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Romain BarrèsNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Steen LarsenDepartment of Biomedical Sciences, Xlab, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark; Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.
Steen S PoulsenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Matthias MannNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
Cathrine ØrskovDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jonas T TreebakNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. Electronic address: jttreebak@sund.ku.dk.
University of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotinamide phosphoribosyltransferase (NAMPT) converts nicotinamide to NAD

Indexed as

AnimalsCytokinesHepatocytesMiceMice, KnockoutMitochondria, LiverNADNicotinamide PhosphoribosyltransferaseNon-alcoholic Fatty Liver DiseaseOxidative PhosphorylationPhenotypeCytokinesNADNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, mousefibrosishepatocytemitochondriaNADNAD(+) biosynthesisNAMPT

Identifiers

PMID34762911
PMCPMC8648833
OpenAlexW3211521906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.