Evidence map›Paper›PMID 34762895›Full record

ArticleJournal of molecular biology2022

Cholesterol-Mediated Clustering of the HIV Fusion Protein gp41 in Lipid Bilayers.

Nhi Tran, Younghoon Oh, Madeleine Sutherland, Qiang Cui, Mei Hong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Solid-State NMR of Virus Membrane Proteins.Accounts of chemical research · 2025
    Article
  3. The Role of Cholesterol in M2 Clustering and Viral Budding Explained.Journal of chemical theory and computation · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nhi TranDepartment of Chemistry, Massachusetts Institute of Technology, 170 Albany Street, Cambridge, MA 02139, United States.
Younghoon OhDepartment of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, United States.
Madeleine SutherlandDepartment of Chemistry, Massachusetts Institute of Technology, 170 Albany Street, Cambridge, MA 02139, United States.
Qiang CuiDepartment of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, United States; Department of Physics, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, United States; Department of Biomedical Engineering, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, United States. Electronic address: meihong@mit.edu.
Mei HongDepartment of Chemistry, Massachusetts Institute of Technology, 170 Albany Street, Cambridge, MA 02139, United States. Electronic address: https://twitter.com/MeiHongLab.
Massachusetts Institute of Technology · USBoston University · US

Funding

Structures and lipid interactions of curvature-inducing membrane peptides by NMRR01GM066976 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HONG, MEI · 2003 to 2021
$4.8M
NIGMS NIH HHS R01 GM066976
6 · The paper itself

Abstract

The envelope glycoprotein (Env) of the human immunodeficient virus (HIV-1) is known to cluster on the viral membrane surface to attach to target cells and cause membrane fusion for HIV-1 infection. However, the molecular structural mechanisms that drive Env clustering remain opaque. Here, we use solid-state NMR spectroscopy and molecular dynamics (MD) simulations to investigate nanometer-scale clustering of the membrane-proximal external region (MPER) and transmembrane domain (TMD) of gp41, the fusion protein component of Env. Using

Indexed as

Virus InternalizationAmino Acid SequenceCholesterolCluster AnalysisHIV-1HIV Envelope Protein gp41HIV InfectionsHumansLipid BilayersMagnetic Resonance SpectroscopyMolecular Dynamics SimulationProtein ConformationProtein DomainsCholesterolHIV Envelope Protein gp41Lipid Bilayers(19)F solid-state NMRmembrane protein clusteringMPERvirus-cell fusion

Identifiers

PMID34762895
PMCPMC8832541
OpenAlexW3213424717

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.