Evidence map›Paper›PMID 34762840›Full record

ArticleThe Lancet. Child & adolescent health2021

Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma.

Victor E Ortega, Michelle Daya, Stanley J Szefler, Eugene R Bleecker, Vernon M Chinchilli, Wanda Phipatanakul, Dave Mauger, Fernando D Martinez, Esther Herrera-Luis, Maria Pino-Yanes and 39 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet. Child & adolescent health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Pharmacogenetics of childhood uncontrolled asthma.Expert review of clinical immunology · 2025
    Review
  4. Asthma-Genomic Advances Toward Risk Prediction.Clinics in chest medicine · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Asthma Exacerbations: The Genes Behind the Scenes.Journal of investigational allergology & clinical immunology · 2023
    Review
  10. Towards precision drug therapy in asthma.Annals of translational medicine · 2022
    Article
  11. Review
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

49 authors at 20 institutions in 1 country.

Victor E OrtegaDepartment of Internal Medicine, Section for Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: ortega.victor@mayo.edu.
Michelle DayaDepartment of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Stanley J SzeflerDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Eugene R BleeckerDepartment of Internal Medicine, Division of Genetics, Genomics, and Precision Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
Vernon M ChinchilliDepartment of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Wanda PhipatanakulDivision of Pediatric Allergy and Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Dave MaugerDepartment of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Fernando D MartinezAsthma and Airway Disease Research Center, University of Arizona Health Sciences, Tucson, AZ, USA.
Esther Herrera-LuisDepartment of Biochemistry, La Laguna, Tenerife, Spain; Microbiology, Cell Biology, and Genetics, La Laguna, Tenerife, Spain; Genomics and Health Group, La Laguna, Tenerife, Spain; Universidad de La Laguna, La Laguna, Tenerife, Spain.
Maria Pino-YanesDepartment of Biochemistry, La Laguna, Tenerife, Spain; Microbiology, Cell Biology, and Genetics, La Laguna, Tenerife, Spain; Genomics and Health Group, La Laguna, Tenerife, Spain; Universidad de La Laguna, La Laguna, Tenerife, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
Gregory A HawkinsDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Elizabeth J AmplefordDepartment of Internal Medicine, Section for Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Susan J KunselmanDepartment of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Corey CoxDepartment of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Leonard B BacharierDepartment of Pediatrics, Washington University School of Medicine, St Louis, MO, USA.
Michael D CabanaDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Juan Carlos CardetDepartment of Internal Medicine, Division of Allergy and Immunology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Mario CastroDepartment of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Loren C DenlingerDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Celeste EngDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Anne M FitzpatrickDepartment of Pediatrics, Emory University, Atlanta, GA, USA.
Fernando HolguinDepartment of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Donglei HuDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Daniel J JacksonDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Nizar JarjourDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Monica KraftDepartment of Internal Medicine, Division of Genetics, Genomics, and Precision Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
Jerry A KrishnanBreathe Chicago Center, Division of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois, Chicago, IL, USA.
Stephen C LazarusDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Robert F LemanskeDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
John J LimaCenter for Pharmacogenomics and Translational Research, Nemours Children's Health System, Jacksonville, FL, USA.
Njira LugogoDepartment of Medicine, Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, USA.
Angel MakDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Wendy C MooreDepartment of Internal Medicine, Section for Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Edward T NaureckasDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Stephen P PetersDepartment of Internal Medicine, Section for Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jacqueline A PongracicDepartment of Pediatrics, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Satria P SajuthiCenter for Genes, Environment, and Health, Department of Pediatrics, National Jewish Health, Denver, CO, USA.
Max A SeiboldDepartment of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA; Center for Genes, Environment, and Health, Department of Pediatrics, National Jewish Health, Denver, CO, USA.
Lewis J SmithDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Julian SolwayDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Christine A SorknessDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Sally WenzelDepartment of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Steven R WhiteDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Esteban G BurchardDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Kathleen BarnesDepartment of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Deborah A MeyersDepartment of Internal Medicine, Division of Genetics, Genomics, and Precision Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
Elliot IsraelDepartment of Pulmonary and Critical Care Medicine and Allergy and Immunology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Michael E WechslerDepartment of Medicine, National Jewish Health, Denver, CO, USA.
NHLBI AsthmaNet
University of California, San Francisco · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Wisconsin–Madison · USUniversity of Arizona · USWake Forest University · USPennsylvania State University · USUniversity of Chicago · USNational Jewish Health · USBoston Children's Hospital · USBrigham and Women's Hospital · USEmory University · USLurie Children's Hospital · USNemours Children's Health System · USNorthwestern University · USUniversity of Illinois Chicago · USUniversity of Kansas Medical Center · USUniversity of Michigan–Ann Arbor · USUniversity of Pittsburgh · USUniversity of South Florida · USWashington University in St. Louis · US

Funding

Data Coordinating Center for the NHLBI Asthma Network (AsthmaNet)U10HL098115 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MAUGER, DAVID T. · 2009 to 2015
$57.6M
Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
AsthmaNet: Brigham and Women's Hospital & Children's Hospital BostonU10HL098102 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ISRAEL, ELLIOT, PHIPATANAKUL, WANDA · 2009 to 2015
$5.5M
Gene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4M
Clinical Centers for the NHLBI Asthma Network (AsthmaNet)U10HL098075 · NHLBI · NATIONAL JEWISH HEALTH · PI SZEFLER, STANLEY J., WECHSLER, MICHAEL E · 2009 to 2015
$5.1M
AsthmaNet: UW-Madison Clinical and Translational Research CenterU10HL098090 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI LEMANSKE, ROBERT F, SORKNESS, CHRISTINE ANNE · 2009 to 2015
$4.8M
UCSF AsthmaNet Clinical CenterU10HL098107 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CABANA, MICHAEL D, LAZARUS, STEPHEN C · 2009 to 2015
$4.8M
AsthmaNet: Phenotypic Influences on Asthma TreatmentsU10HL098177 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOLGUIN, FERNANDO, WENZEL, SALLY E · 2009 to 2015
$4.7M
Arizona/Duke Clinical Center for AsthmaNetU10HL098112 · NHLBI · UNIVERSITY OF ARIZONA · PI KRAFT, MONICA, MARTINEZ, FERNANDO D · 2009 to 2015
$4.7M
Chicagoland Metropolitan AsthmaNet Consortium (CMAC)U10HL098096 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KRISHNAN, JERRY A., PONGRACIC, JACQUELINE · 2009 to 2015
$4.6M
Atlantic Coast Consortium for Asthma (ACC-A) AsthmaNet Clinical SiteU10HL098103 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FITZPATRICK, ANNE MENTRO, PETERS, STEPHEN P · 2009 to 2015
$4.5M
NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001422NHLBI NIH HHS K08 HL118128NHLBI NIH HHS R01 HL141845NHLBI NIH HHS R01 HL142992NHLBI NIH HHS U10 HL098075NHLBI NIH HHS U10 HL098090NHLBI NIH HHS U10 HL098096NHLBI NIH HHS U10 HL098098NHLBI NIH HHS U10 HL098102NHLBI NIH HHS U10 HL098103NHLBI NIH HHS U10 HL098107NHLBI NIH HHS U10 HL098112NHLBI NIH HHS U10 HL098115NHLBI NIH HHS U10 HL098177NIAID NIH HHS K23 AI125785NIDDK NIH HHS R01 DK113003NIEHS NIH HHS R01 ES015794NIMHD NIH HHS R01 MD010443
6 · The paper itself

Abstract

backgroundPharmacogenetic studies in asthma cohorts, primarily made up of White people of European descent, have identified loci associated with response to inhaled beta agonists and corticosteroids (ICSs). Differences exist in how individuals from different ancestral backgrounds respond to long-acting beta agonist (LABA) and ICSs. Therefore, we sought to understand the pharmacogenetic mechanisms regulating therapeutic responsiveness in individuals of African descent.

methodsWe did ancestry-based pharmacogenetic studies of children (aged 5-11 years) and adolescents and adults (aged 12-69 years) from the Best African Response to Drug (BARD) trials, in which participants with asthma uncontrolled with low-dose ICS (fluticasone propionate 50 μg in children, 100 μg in adolescents and adults) received different step-up combination therapies. The hierarchal composite outcome of pairwise superior responsiveness in BARD was based on asthma exacerbations, a 31-day difference in annualised asthma-control days, or a 5% difference in percentage predicted FEV

findingsWe included 249 unrelated children and 267 unrelated adolescents and adults in the BARD pharmacogenetic analysis. In children, we identified a significant admixture mapping peak for superior responsiveness to 5 × ICS versus 100 μg fluticasone plus salmeterol on chromosome 12 (odds ratio [OR

interpretationBARD is the first genome-wide pharmacogenetic study of LABA and ICS response in clinical trials of individuals of African descent to detect and replicate genome-wide significant loci. Admixture mapping of the composite BARD trial outcome enabled the identification of novel pharmacogenetic variation accounting for differential therapeutic responses in people of African descent with asthma.

fundingNational Institutes of Health, National Heart, Lung, and Blood Institute.

Indexed as

Black PeoplePharmacogenomic TestingAdministration, InhalationAdolescentAdrenal Cortex HormonesAdultAsthmaBlack or African AmericanBronchodilator AgentsChildDrug Therapy, CombinationFemaleFluticasoneHumansMaleMiddle AgedAdrenal Cortex HormonesBronchodilator AgentsFluticasoneSalmeterol Xinafoate

Identifiers

PMID34762840
PMCPMC8787857
OpenAlexW3213839954

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.