Evidence map›Paper›PMID 34762786›Full record

ArticleArchives of endocrinology and metabolism2021

The effect of paraoxonase 1 (PON1) gene polymorphisms T(-107)C and L55M and diet composition on serum PON1 activity in women.

Bianka Machado Zanini, Leticia Burkert, Fabiola Goettem Dos Santos, Michal M Masternak, José Augusto Crespo-Ribeiro, Carlos Castilho Barros, Sandra Costa Valle, Augusto Schneider

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Bianka Machado ZaniniDepartamento de Nutrição, Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
Leticia BurkertDepartamento de Nutrição, Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
Fabiola Goettem Dos SantosDepartamento de Nutrição, Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
Michal M MasternakCollege of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.
José Augusto Crespo-RibeiroDepartamento de Ginecologia, Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
Carlos Castilho BarrosDepartamento de Nutrição, Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
Sandra Costa ValleDepartamento de Nutrição, Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
Augusto SchneiderDepartamento de Nutrição, Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brasil, augusto.schneider@ufpel.edu.br.
Universidade Federal de Pelotas · BRUniversity of Central Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate the serum activity of PON1 in women according to SNPs L55M and T-107C and diet composition.

methodsBlood and serum samples from 26 women were used. DNA extraction, PCR and digestion with restriction enzymes of the PCR fragment were performed for genotyping the PON1 SNPs T-107C and L55M. Serum PON1 activity was measured in a single time point. Patients completed the semi-quantitative food frequency questionnaire and diet composition was estimated.

resultsGenotypic distribution for L55M SNP was 56% for the LL genotype, 32% for LM and 12% for MM; for the PON1 C(-107)T SNP it was 28% for the TT genotype, 41% for CT and 31% for CC. Individuals with C and L alleles had higher serum PON1 activity. Combining the two SNPs, we observed that individuals carrying the LL and CC genotypes had twice the activity of carriers of the TT and MM genotypes. Considering food intake, no significant difference was observed between genotypes and intake levels.

conclusionPON1 T(-107)C and L55M SNPs exert a strong effect on serum PON1 activity in an additive manner and are more important than diet to predict serum PON1 activity.

Indexed as

AryldialkylphosphataseDietPolymorphism, Single NucleotideAllelesFemaleGenotypeHumansAryldialkylphosphatasePON1 protein, humanatherosclerosiscardiovascular diseaseHDLnutrigeneticsSNPs

Identifiers

PMID34762786
PMCPMC10065380
OpenAlexW3212149503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.