Evidence map›Paper›PMID 34762777›Full record

ArticlePhysiological reports2021

Oral vitamin C restores endothelial function during acute inflammation in young and older adults.

Elizabeth C Lefferts, Brooks A Hibner, Wesley K Lefferts, Natalia S Lima, Tracy Baynard, Jacob M Haus, Abbi D Lane-Cordova, Shane A Phillips, Bo Fernhall

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Elizabeth C LeffertsDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID 0000-0002-7538-8228
Brooks A HibnerDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.
Wesley K LeffertsDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID 0000-0001-5957-391X
Natalia S LimaDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.
Tracy BaynardDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.
Jacob M HausSchool of Kinesiology, University of Michigan, Ann Arbor, Michigan, USA.
Abbi D Lane-CordovaDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
Shane A PhillipsDepartment of Physical Therapy, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID 0000-0001-6030-2367
Bo FernhallDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.
University of Illinois Chicago · USIowa State University · USUniversity of Michigan · USUniversity of South Carolina · US

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Precision Lifestyle Medicine and Translation Research (PREMIER)T32HL134634 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI RACHEL CASKEY, Jun Ma · 2018 to 2026
$2.4M
NCATS NIH HHS UL1 TR002003NHLBI NIH HHS T32 HL134634NIDDK NIH HHS P30 DK020572
6 · The paper itself

Abstract

Oxidative stress has been linked to reductions in vascular function during acute inflammation in young adults; however, the effect of acute inflammation on vascular function with aging is inconclusive. The aim of this study was to determine if oral antioxidant administration eliminates vascular dysfunction during acute inflammation in young and older adults. Brachial flow-mediated dilation (FMD) and carotid-femoral pulse wave velocity (PWV) were measured in nine young (3 male, 24 ± 4 yrs, 26.2 ± 4.9 kg/m

Indexed as

Administration, OralAdolescentAdultAgedAgingAnti-Inflammatory AgentsAscorbic AcidC-Reactive ProteinEndothelium, VascularFemaleHumansInterleukin-6MaleMiddle AgedPulse Wave AnalysisVitaminsAnti-Inflammatory AgentsAscorbic AcidC-Reactive ProteinInterleukin-6Vitaminsantioxidantascorbateflow-mediated dilationpulse wave velocity

Identifiers

PMID34762777
PMCPMC8582295
OpenAlexW3214366721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.