ArticleJournal of clinical laboratory analysis2021
Molecular genotyping of G6PD mutations for neonates in Ningbo area.
Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Association between G6PD gene variants and adverse pregnancy outcomes.BMC pregnancy and childbirth · 2026Article
- Screening results and mutation frequency analysis of G6PD deficiency in 1,291,274 newborns in Huizhou, China: a twenty-year experience.Annals of hematology · 2024Article
- An Approach to Re-evaluate the Reference Cutoff of the Parameters of Newborn Screening: An Observational Study.Cureus · 2023Article
- Molecular epidemiological investigation of G6PD deficiency in Yangjiang region, western Guangdong province.Frontiers in genetics · 2023Article
- Molecular genotyping of G6PD mutations for neonates in Ningbo area.Journal of clinical laboratory analysis · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The aim of this study is to determine the cut-off value of glucose-6-phosphate dehydrogenase (G6PD) activity and the mutation spectrum of G6PD gene in neonates with G6PD deficiency at Ningbo. Around 82233 neonatal blood samples were measured to determine G6PD activity. The positive samples were further detected with gene analysis. A total of 445 neonates were confirmed as G6PD deficiency, and the incidence in Ningbo was 1/185. 17 types of G6PD gene mutations were found, including 11 single-site mutations and 6 double-site mutations. Considering the significant differences in G6PD activity, the cut-off value was detected to be 2.35 and 3.65 U/gHb for males and females, respectively. Significant differences in G6PD activities were noted and found to be varied from 4.61 to 6.02 U/gHb in different seasons (p < 0.0001). G6PD deficiency screening is a significant detection test for neonatal G6PD deficiency prevention. Our study highlights that the screening should be done using different cut-off values according to the sexes in different seasons.
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Registered trials
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