ArticleJCI insight2021
Inhibition of the renin-angiotensin system causes concentric hypertrophy of renal arterioles in mice and humans.
Article in JCI insight, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Targeting liver angiotensinogen with siRNA enhances podocyte regeneration through renin lineage cells in experimental kidney disease.Molecular therapy. Nucleic acids · 2026Article
- Renin cells orchestrate a neuro-endocrine microenvironment of the kidney arterial tree in health and disease.JCI insight · 2026Article
- Krüppel-like factor 2 regulates renin expression in mature juxtaglomerular cells.American journal of physiology. Renal physiology · 2026Article
- Balancing Blood Pressure Targets and Kidney Health: The Potential Risk of Kidney Disease Due to Concentric Arterial and Arteriolar Hypertrophy From Renin-Angiotensin-Aldosterone Inhibitors.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Hypoxia-Induced Metabolic Reprogramming and Markings of Cell Fate in Concentric Arterial Hypertrophy.bioRxiv : the preprint server for biology · 2025Article
- Bright Cells, and Inefficient Enzymatic Activity in a Renin Hypomorph Mouse.bioRxiv : the preprint server for biology · 2025Article
- Renal damage-induced hepcidin accumulation contributes to anemia in angiotensinogen-deficient mice.Clinical science (London, England : 1979) · 2025Article
- Kidney Arteriolar Responses to Liver-Targeted Small Interference RNA Targeting Angiotensinogen in Diabetic Rats: Comparison With Other Renin-Angiotensin System Blockers.Journal of the American Heart Association · 2025Article
- Small Interfering RNA Therapy for the Management and Prevention of Hypertension.Current hypertension reports · 2025Review
- Piezo channels in JG cells do not regulate renin expression or renin release to the circulation.Clinical science (London, England : 1979) · 2024Article
- Heterogeneous afferent arteriolopathy: a key concept for understanding blood pressure-dependent renal damage.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Transformation of the Kidney into a Pathological Neuro-Immune-Endocrine Organ.Circulation research · 2024Article
- Podocyte-targeted therapies - progress and future directions.Nature reviews. Nephrology · 2024Review
- An efficient inducible model for the control of gene expression in renin cells.American journal of physiology. Renal physiology · 2024Article
- Mechanism of protective actions of sparsentan in the kidney: lessons from studies in models of chronic kidney disease.Clinical science (London, England : 1979) · 2024Review
- Roles of Integrin in Cardiovascular Diseases: From Basic Research to Clinical Implications.International journal of molecular sciences · 2024Review
- Elusive and Heterogenous Nature of Renin Cells.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Factors associated with non-treatment of hypertension and gender differences at baseline in the ELSA-Brasil cohort.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2024Article
- Renin Cells, From Vascular Development to Blood Pressure Sensing.Hypertension (Dallas, Tex. : 1979) · 2023Review
- Cells of the renin lineage promote kidney regeneration post-release of ureteral obstruction in neonatal mice.Acta physiologica (Oxford, England) · 2023Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Inhibitors of the renin-angiotensin system (RAS) are widely used to treat hypertension. Using mice harboring fluorescent cell lineage tracers, single-cell RNA-Seq, and long-term inhibition of RAS in both mice and humans, we found that deletion of renin or inhibition of the RAS leads to concentric thickening of the intrarenal arteries and arterioles. This severe disease was caused by the multiclonal expansion and transformation of renin cells from a classical endocrine phenotype to a matrix-secretory phenotype: the cells surrounded the vessel walls and induced the accumulation of adjacent smooth muscle cells and extracellular matrix, resulting in blood flow obstruction, focal ischemia, and fibrosis. Ablation of the renin cells via conditional deletion of β1 integrin prevented arteriolar hypertrophy, indicating that renin cells are responsible for vascular disease. Given these findings, prospective morphological studies in humans are necessary to determine the extent of renal vascular damage caused by the widespread use of inhibitors of the RAS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.