ArticleEuropean journal of endocrinology2021
Effect of the transition from more than adequate iodine to adequate iodine on national changes in the prevalence of thyroid disorders: repeat national cross-sectional surveys in China.
Article in European journal of endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Correlations between iodine status and the risk of thyroid nodules, a systematic review and dose-response meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Effect of iodine nutritional status on the recurrence of hyperthyroidism and antithyroid drug efficacy in adult patients with Graves' disease: a systemic review.Frontiers in endocrinology · 2023Pooled it
- Beyond iodine nutrition: socioeconomic patterns independently drive thyroid disease risk in pregnant women in Xinjiang.Frontiers in nutrition · 2026Article
- Oyster shells water extract ameliorates propylthiouracil-induced goitre in rats via PI3K/AKT/Bcl-2 pathway.NPJ science of food · 2025Article
- Urinary iodine levels and thyroid disorder prevalence in the adult population of China: a large-scale population-based cross-sectional study.Scientific reports · 2025Article
- Effects of Trace Elements on Endocrine Function and Pathogenesis of Thyroid Diseases-A Literature Review.Nutrients · 2025Review
- Bifidobacterium depletion promotes goiter via gut-thyroid axis: evidence from Mendelian randomization and experimental validation.Frontiers in microbiology · 2025Article
- Investigating serum iodine nutritional levels and their correlation with thyroid function in adult patients with Graves' hyperthyroidism at different treatment stages.Frontiers in endocrinology · 2025Article
- The common pathogenesis of nodular goiter in both sexes: An exploration into gene expression and signaling pathways.Heliyon · 2024Article
- Iodine status and its association with prevalence of thyroid diseases in adults from Jiangxi Province, China.Endocrine · 2023Article
- Application of oral inorganic iodine in the treatment of Graves' disease.Frontiers in endocrinology · 2023Review
- Systemic Lupus Erythematosus Patients With Related Organic Damage Are at High Risk of Hypothyroidism.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLongitudinal studies have investigated the effects of changing iodine status on thyroid disorders, but the effect of a transition from more than adequate iodine to adequate iodine on national changes in prevalence adjusted for changing risk factors remains unclear.
designTwo repeat nationwide surveys were conducted from 2009-2010 to 2015-2017 to assess changes in thyroid disorder prevalence and iodine status in China.
methodsA multistage stratified random sampling method was used to obtain a nationally representative sample of urban adults aged 18 and older in mainland China in 2009 (n = 14 925) and 2015 (n = 12 553). Changes in thyroid disorder prevalence, urinary iodine concentration (UIC), and thyroid-stimulating hormone (TSH) levels were assessed. Logistic regression models were used to examine changes in prevalence over time.
resultsThe median UIC decreased significantly from 219.7 to 175.9 μg/L (P < 0.0001). The weighted prevalence of overt hyperthyroidism, subclinical hyperthyroidism, Graves' disease, and goitre decreased between 2009 and 2015 in the overall population (P < 0.05 for all). Despite no significant changes in subclinical hyperthyroidism or hypothyroidism or anti-thyroid peroxidase or anti-thyroglobulin antibody positivity prevalence, a significant increase in thyroid nodule prevalence (P < 0.0001) was found in the overall population. The 2.5th TSH percentile increased by 0.15 mIU/L (95% CI: 0.01 to 0.30 mIU/L, P = 0.04) from 2009 to 2015.
conclusionsWith the iodine status transition from more than adequate to adequate, thyroid disorder (except for thyroid nodules) prevalence remained stable or even decreased after adjusting for confounding factors among adults in mainland China between 2009 and 2015. Additional studies are needed to explore the reasons for the increased thyroid nodule prevalence.
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