Evidence map›Paper›PMID 34762528›Full record

Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2022

Endothelin receptor blockade blunts the pressor response to acute stress in men and women with obesity.

Cassandra C Derella, Anson M Blanks, Xiaoling Wang, Matthew A Tucker, Chase Horsager, Jin Hee Jeong, Paula Rodriguez-Miguelez, Jacob Looney, Jeffrey Thomas, David M Pollock and 1 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Endothelin-1 as a novel target for the prevention of metabolic dysfunction with intermittent hypoxia in male participants.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Cassandra C DerellaDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.ORCID 0000-0003-1649-9347
Anson M BlanksDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.ORCID 0000-0002-5366-8376
Xiaoling WangDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.
Matthew A TuckerDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.
Chase HorsagerDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.
Jin Hee JeongDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.ORCID 0000-0002-8748-8429
Paula Rodriguez-MiguelezDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.ORCID 0000-0003-3582-4483
Jacob LooneyDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.
Jeffrey ThomasDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.
David M PollockDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-0233-2362
Ryan A HarrisDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.ORCID 0000-0002-8826-681X
Augusta University · USUniversity of Alabama at Birmingham · USUniversity of Ulster · GBVirginia Commonwealth University · US

Funding

Vascular and renal responses to stressP01HL069999 · NHLBI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI HARSHFIELD, GREGORY ALAN · 2002 to 2018
$31.1M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
NHLBI NIH HHS 5P01HL069999NHLBI NIH HHS P01 HL069999NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

Obesity is associated with dysregulation of the endothelin system. In individuals with obesity, an exaggerated pressor response to acute stress is accompanied by increased circulating endothelin-1 (ET-1). The impact of combined endothelin A/B receptor (ET

Indexed as

ObesityOverweightBlood PressureEndothelin-1Endothelin B Receptor AntagonistsEndothelin Receptor AntagonistsEndothelinsFemaleHumansMaleReceptor, Endothelin AEndothelin-1Endothelin B Receptor AntagonistsEndothelin Receptor AntagonistsEndothelinsReceptor, Endothelin Ablood pressurebosentanendothelin-1obesitystress

Identifiers

PMID34762528
PMCPMC8742738
OpenAlexW3213998193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.