ArticleScience (New York, N.Y.)2021
Ligand-controlled divergent dehydrogenative reactions of carboxylic acids via C-H activation.
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 126 citations in OpenAlex.
- Ligand-Enabled Stereoselective Coupling of Methylene C(spAngewandte Chemie (International ed. in English) · 2026Article
- Three-site cycloadditions within one reaction intermediate with site-selectivity controlled by electronic and size bias.Nature communications · 2026Article
- Article
- Catalyst-controlled site-selective dehydrogenation, a stepping stone for C-H oxidations in complex terpenes synthesis.Nature communications · 2026Article
- A general photoinduced manganese-catalyzed platform for the sequential difunctionalization of [1.1.1]propellane.Science advances · 2026Article
- Direct arylation polymerization of electron-rich arenes with polar-group tolerance enabled by ligand-coordination tuning.Chemical science · 2026Article
- Formal Diels-Alder reaction of saturated carboxylic acids via C-H activation.Nature chemistry · 2026Article
- Transition Metal-Catalyzed Direct C(spChemical reviews · 2026Review
- Biocatalytic site- and stereoselective carbonyl desaturation for late-stage functionalization of cyclic ketones.Nature chemistry · 2026Article
- Site-Selective Benzylic Dehydrogenation of Alkylindoles.JACS Au · 2025Article
- From Mono-Accounts of chemical research · 2025Review
- Transition-Metal-Catalyzed C(spTopics in current chemistry (Cham) · 2025Review
- Versatile Butenolide Syntheses via a Structure-Oriented C-H Activation Reaction.Journal of the American Chemical Society · 2025Article
- Palladium-Catalyzed Methylene β-C-H Fluorination of Native Amides.Journal of the American Chemical Society · 2025Article
- Copper-Catalyzed Cyclization and Alkene Transposition Cascade Enables a Modular Synthesis of Complex Spirocyclic Ethers.Journal of the American Chemical Society · 2025Article
- Unmasking the reverse catalytic activity of 'ene'-reductases for asymmetric carbonyl desaturation.Nature chemistry · 2025Article
- Synthesis of Chiral Carbocycles via Enantioselective β,γ-Dehydrogenation.Nature synthesis · 2024Article
- Catalyst-Controlled Chemoselective γ-C(spJournal of the American Chemical Society · 2024Article
- Radical-triggered translocation of C-C double bond and functional group.Nature chemistry · 2024Article
- One-Step Synthesis of Chiral 9,10-Dihydrophenanthrenes via Ligand-Enabled Enantioselective Cascade β,γ-Diarylation of Acids.Angewandte Chemie (International ed. in English) · 2024Article
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7 authors at 2 institutions in 2 countries.
Funding
Abstract
Dehydrogenative transformations of alkyl chains to alkenes through methylene carbon-hydrogen (C–H) activation remain a substantial challenge. We report two classes of pyridine-pyridone ligands that enable divergent dehydrogenation reactions through palladium-catalyzed β-methylene C–H activation of carboxylic acids, leading to the direct syntheses of α,β-unsaturated carboxylic acids or γ-alkylidene butenolides. The directed nature of this pair of reactions allows chemoselective dehydrogenation of carboxylic acids in the presence of other enolizable functionalities such as ketones, providing chemoselectivity that is not possible by means of existing carbonyl desaturation protocols. Product inhibition is overcome through ligand-promoted preferential activation of C(sp
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.