ArticleScience (New York, N.Y.)2021
Computed structures of core eukaryotic protein complexes.
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Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 300 papers.
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300citing papers in PubMed
36.7field-weighted citation impact, top 1% of its field
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300 citing papers in PubMed, 553 citations in OpenAlex.
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- Inferring dynamic information from protein structures by Gaussian integrals and deep learning.Bioinformatics (Oxford, England) · 2026Article
- When can AlphaFold predict the oligomeric states of proteins?Protein science : a publication of the Protein Society · 2026Article
- Structural insights into predicted protein-protein interactions and protein complexes in the human proteome.Scientific reports · 2026Article
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- The evolving role of structural biology in pharma: integration of X-ray crystallography, cryo-electron microscopy and beyond.Acta crystallographica. Section D, Structural biology · 2026Review
- ProteomeLM: A proteome-scale language model enables accurate and rapid prediction of protein-protein interactions and gene essentiality across taxa.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- FlyPredictome: A structural atlas of predicted protein-protein interactions inbioRxiv : the preprint server for biology · 2026Article
- T3SS effector and regulator discovery by predicting interacting partners of T3SS chaperones in Pseudomonas aeruginosa.Protein science : a publication of the Protein Society · 2026Article
240 more citing papers are in PubMed but not listed here.
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Authors and funding
30 authors at 13 institutions in 4 countries.
Ian R Humphreys *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3058-6714
Jimin Pei *Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-3505-9665
Minkyung Baek *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-3414-9404
Aditya Krishnakumar *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-3461-0133
Ivan AnishchenkoDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-3645-2044
Sergey OvchinnikovFaculty of Arts and Sciences, Division of Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-2774-2744
Jing ZhangEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-4190-3065
Travis J NessDepartment of Chemistry, Wayne State University, Detroit, MI, USA.ORCID 0000-0002-4828-0609
Sudeep BanjadeDepartment of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA.
Saket R BagdeDepartment of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA.ORCID 0000-0001-9800-9326
Viktoriya G StanchevaMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.ORCID 0000-0001-5188-297X
Xiao-Han LiMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.ORCID 0000-0002-6007-5149
Kaixian LiuMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-9711-6509
Zhi ZhengMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-0867-7334
Daniel J BarreroHoward Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Upasana RoyDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-8126-9698
Jochen KuperRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.ORCID 0000-0001-7553-5825
Israel S FernándezDepartment of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.
Barnabas SzakalIFOM, the FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy.ORCID 0000-0001-6888-1383
Dana BranzeiIFOM, the FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy.ORCID 0000-0002-0544-4888
Josep RizoDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-1773-8311
Caroline KiskerRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.ORCID 0000-0002-0216-6026
Eric C GreeneDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-7387-824X
Sue BigginsHoward Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID 0000-0002-4499-6319
Scott KeeneyMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-1283-6417
Elizabeth A MillerMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.ORCID 0000-0002-1033-8369
J Christopher FrommeDepartment of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-8837-0473
Tamara L HendricksonDepartment of Chemistry, Wayne State University, Detroit, MI, USA.ORCID 0000-0002-4947-005X
Qian Cong *Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8909-0414
David Baker *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7896-6217
University of Washington · USCornell University · USHoward Hughes Medical Institute · USMemorial Sloan Kettering Cancer Center · USMRC Laboratory of Molecular Biology · GBSouthwestern Medical Center · USColumbia University · USIFOM · ITUniversity of Würzburg · DEWayne State University · USHarvard University · USSt. Jude Children's Research Hospital · USThe University of Texas Southwestern Medical Center · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MMechanisms of neurotransmitter release and its regulationR35NS097333 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI RIZOREY, JOSE · 2017 to 2024
$7.0MProtein purification instrumentation in support of single molecule studies of genome integrityR35GM118026 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENE, ERIC C · 2016 to 2025
$5.7MGTPase Regulation of the Golgi Complex (Diversity Supplement 2023)R35GM136258 · NIGMS · CORNELL UNIVERSITY · PI J Christopher Fromme · 2020 to 2026
$4.0MDefining the contributions of BRCA1, BRCA2, and RAD52 to genome stabilityR01CA221858 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENE, ERIC C · 2020 to 2024
$1.9MStructural analysis of inner membrane platform in the type 2 secretion systemR21AI156595 · NIAID · YALE UNIVERSITY · PI MI, WEI · 2021 to 2022
$492kMedical Research Council MC_UP_1201/10NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA221858NIAID NIH HHS R21 AI156595NIGMS NIH HHS R35 GM118026NIGMS NIH HHS R35 GM136258NINDS NIH HHS R35 NS097333
Abstract
Protein-protein interactions play critical roles in biology, but the structures of many eukaryotic protein complexes are unknown, and there are likely many interactions not yet identified. We take advantage of advances in proteome-wide amino acid coevolution analysis and deep-learning–based structure modeling to systematically identify and build accurate models of core eukaryotic protein complexes within the
Indexed as
Deep LearningProtein Interaction MappingAcyltransferasesChromosome SegregationComputational BiologyComputer SimulationDNA RepairEvolution, MolecularHomologous RecombinationLigasesMembrane ProteinsModels, MolecularMultiprotein ComplexesProtein BiosynthesisProtein ConformationProtein Interaction MapsAcyltransferasesCOOH-terminal signal transamidaseLigasesMembrane ProteinsMultiprotein ComplexesProteomeSaccharomyces cerevisiae ProteinsUbiquitin
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