ArticleJournal of agricultural and food chemistry2021
Chemoinformatics View on Bitter Taste Receptor Agonists in Food.
Article in Journal of agricultural and food chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- De novo design and experimental characterization of bitter peptides.NPJ science of food · 2026Article
- An integrated machine learning framework for TCM five-flavor classification based on E-tongue profiling and SHAP analysis.Chinese medicine · 2026Article
- A homoeriodictyol sodium mouthwash reduces bitterness sensitivity in patients with gynecological cancer receiving carboplatin-based chemotherapy.Scientific reports · 2026Article
- Activation of Extraoral Bitter Taste Receptors by Herbs and Spices in the Regulation of Incretin Signaling and Glucose Metabolism.Nutrition reviews · 2026Review
- Chemosensory response to Pt-based chemotherapeutics via bitter taste receptors in vitro reveals a new mechanism for bitter taste disorders.Scientific reports · 2026Article
- Homoeriodictyol, targeting the bitter taste receptor TAS2R14, lowers the secretion of pro-inflammatory chemokines upon treatment with SARS-CoV-2 peptide pools in human peripheral blood mononuclear cells.Frontiers in immunology · 2026Article
- Genetic Variants Increasing TAS2R38 Bitter Taste Receptor Sensitivity Are Associated With Lower Postprandial Glycemia.Diabetes · 2025Article
- Subchronic modulation of bitter taste receptors (TAS2R) by procyanidins. Unravelling the complex interplay between stimulation and expression.Journal of physiology and biochemistry · 2025Article
- A chemical language model for molecular taste prediction.NPJ science of food · 2025Article
- Taste-Guided Isolation of Bitter Compounds from the MushroomJournal of agricultural and food chemistry · 2025Article
- Bitter taste receptors as sensors of gut luminal contents.Nature reviews. Gastroenterology & hepatology · 2025Review
- Identification of 4'-Demethyl-3,9-dihydroeucomin as a Bitter-Masking Compound from the Resin ofJournal of agricultural and food chemistry · 2024Article
- Article
- Sensing of luminal contents and downstream modulation of GI function.JGH open : an open access journal of gastroenterology and hepatology · 2024Review
- Article
- Profiling bitter taste receptors (TAS2R) along the gastrointestinal tract and their influence on enterohormone secretion. Gender- and age-related effects in the colon.Frontiers in endocrinology · 2024Article
- The taste for health: the role of taste receptors and their ligands in the complex food/health relationship.Frontiers in nutrition · 2024Article
- Article
- Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor.Molecular nutrition & food research · 2023Article
- Data-Driven Elucidation of Flavor Chemistry.Journal of agricultural and food chemistry · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Food compounds with a bitter taste have a role in human health, both for their capability to influence food choice and preferences and for their possible systemic effect due to the modulation of extra-oral bitter taste receptors (TAS2Rs). Investigating the interaction of bitter food compounds with TAS2Rs is a key step to unravel their complex effects on health and to pave the way to rationally design new additives for food formulation or drugs. Here, we propose a collection of food bitter compounds, for which in vitro activity data against TAS2Rs are available. The patterns of TAS2R subtype-specific agonists were analyzed using scaffold decomposition and chemical space analysis, providing a detailed characterization of the associations between food bitter tastants and TAS2Rs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.