Evidence map›Paper›PMID 34762352›Full record

ArticlePhysiological reports2021

Contribution of analog signaling to neurotransmitter interactions and behavior: Role of transporter-mediated nonquantal dopamine release.

Viktor Román, Rita Kedves, Kristóf Kelemen, Zsolt Némethy, Beáta Sperlágh, Balázs Lendvai, E Sylvester Vizi

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Viktor RománPharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Rita KedvesPharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Kristóf KelemenPharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Zsolt NémethyPharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Beáta SperlághInstitute of Experimental Medicine, Budapest, Hungary.
Balázs LendvaiPharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
E Sylvester ViziInstitute of Experimental Medicine, Budapest, Hungary.ORCID 0000-0002-9557-4597
Gedeon Richter (Hungary) · HUHUN-REN Institute of Experimental Medicine · HUSemmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuronal networks cause changes in behaviorally important information processing through the vesicular release of neurotransmitters governed by the rate and timing of action potentials (APs). Herein, we provide evidence that dopamine (DA), nonquantally released from the cytoplasm, may exert similar effects in vivo. In mouse slice preparations, (+/-)-3,4-methylenedioxy-methamphetamine (MDMA, or ecstasy) and β-phenylethylamine (β-PEA)-induced DA release in the striatum and nucleus accumbens (NAc), two regions of the brain involved in reward-driven and social behavior and inhibited the axonal stimulation-induced release of tritiated acetylcholine ([

Indexed as

Signal TransductionSocial BehaviorAnimalsCorpus StriatumDopamineDopamine D2 Receptor AntagonistsDopamine Plasma Membrane Transport ProteinsMaleMiceN-Methyl-3,4-methylenedioxyamphetamineNucleus AccumbensPhenethylaminesPsychotropic DrugsRatsRats, WistarReceptors, Dopamine D2DopamineDopamine D2 Receptor AntagonistsDopamine Plasma Membrane Transport ProteinsN-Methyl-3,4-methylenedioxyamphetaminephenethylaminePhenethylaminesPsychotropic DrugsReceptors, Dopamine D2SerotoninSulpiridecytoplasmic releasedopaminenonquantalsocial behaviortransporter

Identifiers

PMID34762352
PMCPMC8582292
OpenAlexW3213096666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.