ArticleChemistry (Weinheim an der Bergstrasse, Germany)2022
Total Synthesis and Structural Assignment of (-)-Fusaequisin A.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Structurally diverse secondary metabolites from the dung-inhabiting fungus Botryotrichum murorum.Scientific reports · 2026Article
- DeepSA: a deep-learning driven predictor of compound synthesis accessibility.Journal of cheminformatics · 2023Article
- Total Synthesis and Structural Assignment of (-)-Fusaequisin A.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
(-)-Fusaequisin A is an irregularly assembled polyketide isolated from the ascomycete Fusarium equiseti. Fusaequisin A shares a carbon backbone with curvicollide C from the ascomycete Podospora curvicolla but its absolute configuration remained hitherto unsettled. Herein, we document the total synthesis of (-)-fusaequisin A and its 4-O-desmethyl derivative following a central-to-lateral building block strategy. Catalytic asymmetric Claisen rearrangement, Julia-Kocienski olefination and olefin cross-metathesis served as key C/C-connecting transformations. The constitution and absolute configuration of (-)-fusaequisin A was deduced and the original structural assignment was adjusted.
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