ReviewGeroScience2021
The aging venous system: from varicosities to vascular cognitive impairment.
Review in GeroScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Direct Vascular Effects of Angiotensin II (A Systematic Short Review).International journal of molecular sciences · 2024Pooled it
- Review
- Cerebral Venous Insufficiency as a Contributing Factor in Dementia: An Emerging Hypothesis.Stroke (Hoboken, N.J.) · 2026Review
- A survey of self-reported varicose veins with prior clinical diagnosis among adults residing in the United Arab Emirates: a cross-sectional study examining associated factors.Frontiers in epidemiology · 2026Article
- Impact of hemodynamic doppler ultrasound parameters on patency and post-thrombotic syndrome in patients with iliofemoral venous stents.Scientific reports · 2025Article
- Skeletal muscle oxygenation and fluid content in upper extremity postthrombotic syndrome: a proof-of-concept study.Research and practice in thrombosis and haemostasis · 2025Article
- Roadmap for alleviating the manifestations of ageing in the cardiovascular system.Nature reviews. Cardiology · 2025Review
- Clinical Outcomes of Surgical Revascularization in Patients Presenting with Critical Limb Ischemia and Aortic Valve Stenosis.Journal of cardiovascular development and disease · 2025Article
- Ultrasound Evaluation of Internal Jugular Venous Insufficiency and Its Association with Cognitive Decline.Diagnostics (Basel, Switzerland) · 2025Article
- Trends and outcomes of inpatient cardiac implantable electronic device transvenous lead extractions: a nationwide analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Functions and application of circRNAs in vascular aging and aging-related vascular diseases.Journal of nanobiotechnology · 2025Review
- Age as a key risk factor for deep vein thrombosis in patients with lower limb cellulitis.Frontiers in medicine · 2025Article
- Aging diastole - root cause for atrial fibrillation and heart failure with preserved ejection fraction.The journal of cardiovascular aging · 2024Article
- Article
- Assessing the effectiveness of targeted educational interventions on enhancing self-efficacy and foot care practices among diabetic women in Jordan.Frontiers in public health · 2024Article
- Connecting epigenetics and inflammation in vascular senescence: state of the art, biomarkers and senotherapeutics.Frontiers in genetics · 2024Review
- Venous dilation effect of hot towel (moist and dry heat) versus hot pack for peripheral intravenous catheterization: a quasi-experimental study.Journal of physiological anthropology · 2023Article
- Dependent Leg Edema in Older Patients with or without Skin Lesion.Annals of vascular diseases · 2023Article
- Review
- Echocardiographic findings focused on the inferior vena cava partly aid the diagnosis of cardiac amyloidosis.European heart journal · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging-induced pathological alterations of the circulatory system play a critical role in morbidity and mortality of older adults. While the importance of cellular and molecular mechanisms of arterial aging for increased cardiovascular risk in older adults is increasingly appreciated, aging processes of veins are much less studied and understood than those of arteries. In this review, age-related cellular and morphological alterations in the venous system are presented. Similarities and dissimilarities between arterial and venous aging are highlighted, and shared molecular mechanisms of arterial and venous aging are considered. The pathogenesis of venous diseases affecting older adults, including varicose veins, chronic venous insufficiency, and deep vein thrombosis, is discussed, and the potential contribution of venous pathologies to the onset of vascular cognitive impairment and neurodegenerative diseases is emphasized. It is our hope that a greater appreciation of the cellular and molecular processes of vascular aging will stimulate further investigation into strategies aimed at preventing or retarding age-related venous pathologies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.