Evidence map›Paper›PMID 34762211›Full record

Trial reportMetabolic brain disease2022

Moderate-intensity continuous training and high-intensity interval training improve cognition, and BDNF levels of middle-aged overweight men.

Neumir Sales de Lima, Ricardo Augusto Leoni De Sousa, Fabiano Trigueiro Amorim, Fernando Gripp, Caíque Olegário Diniz E Magalhães, Samuel Henrique Pinto, Marco Fabrício Dias Peixoto, Renato Sobral Monteiro-Junior, Kelsey Bourbeau, Ricardo Cardoso Cassilhas

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Metabolic brain disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07248709 (Comparison of High-Intensity Interval Training and Moderate-Intensity Continuous Training on Executive Functions, Cardiorespiratory and Physical Fitness in Older Adults With Mild Cognitive Impairment), which is not on this map. Cited by 27 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 6 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07248709 nacompletednot on this mapstarted 2025, after this paper: background citation

Comparison of High-Intensity Interval Training and Moderate-Intensity Continuous Training on Executive Functions, Cardiorespiratory and Physical Fitness in Older Adults With Mild Cognitive Impairment

TypeinterventionalSponsorRiphah International UniversityRan2025 to 2026Enrolled68ConditionsMild Cognitive ImpairmentArmsHigh-Intensity Interval Training (HIIT), Moderate-Intensity Continuous Training
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 6 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Review
  11. Review
  12. Associations between muscle strength and mental health in older adults.Revista da Associacao Medica Brasileira (1992) · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 5 countries.

Neumir Sales de LimaPhysical Education Department, Federal University of the Valleys of Jequitinhonha and Mucuri (UFVJM), Rodovia MGT 367 - Km 583, n° 5000, Diamantina, MG, CEP 39100-000, Brazil.
Ricardo Augusto Leoni De SousaPhysical Education Department, Federal University of the Valleys of Jequitinhonha and Mucuri (UFVJM), Rodovia MGT 367 - Km 583, n° 5000, Diamantina, MG, CEP 39100-000, Brazil.
Fabiano Trigueiro AmorimDepartment of Health, Exercise & Sports Sciences, University of New Mexico, Albuquerque, USA.
Fernando GrippPhysical Education Department, Federal University of the Valleys of Jequitinhonha and Mucuri (UFVJM), Rodovia MGT 367 - Km 583, n° 5000, Diamantina, MG, CEP 39100-000, Brazil.
Caíque Olegário Diniz E MagalhãesPhysical Education Department, Federal University of the Valleys of Jequitinhonha and Mucuri (UFVJM), Rodovia MGT 367 - Km 583, n° 5000, Diamantina, MG, CEP 39100-000, Brazil.
Samuel Henrique PintoPhysical Education Department, Federal University of the Valleys of Jequitinhonha and Mucuri (UFVJM), Rodovia MGT 367 - Km 583, n° 5000, Diamantina, MG, CEP 39100-000, Brazil.
Marco Fabrício Dias PeixotoPhysical Education Department, Federal University of the Valleys of Jequitinhonha and Mucuri (UFVJM), Rodovia MGT 367 - Km 583, n° 5000, Diamantina, MG, CEP 39100-000, Brazil.
Renato Sobral Monteiro-JuniorPhysical Education and Sport Department, State University of Montes Claros, Montes Claros, MG, Brazil.
Kelsey BourbeauDepartment of Health, Exercise & Sports Sciences, University of New Mexico, Albuquerque, USA.
Ricardo Cardoso CassilhasPhysical Education Department, Federal University of the Valleys of Jequitinhonha and Mucuri (UFVJM), Rodovia MGT 367 - Km 583, n° 5000, Diamantina, MG, CEP 39100-000, Brazil. rcassilhas@yahoo.com.br.ORCID http://orcid.org/0000-0001-6970-2551
Department of Physiological Sciences · RUUniversity of New Mexico · USUniversidade Estadual de Montes Claros · BRUniversidade Federal dos Vales do Jequitinhonha e Mucuri · BRYahoo (Spain) · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of overweight and obesity is increasing worldwide, which has been associated with poor cognitive outcomes. Participating in regular physical exercise may also improve cognition, and levels of brain-derived neurotrophic factor (BDNF), but the optimal exercise prescription remains to be elucidated. The purpose of the present study is to compare the effects of moderate intensity continuous training (MICT) and high intensity interval training (HIIT) on cognition, and serum BDNF levels in middle-aged and overweight men. Twenty-five sedentary, overweight men participated in the 8-week training intervention. Subjects were randomized into MICT (n = 12) or HIIT (n = 13) and performed exercise sessions 3x/week for 8-weeks. Cognitive function, and serum BDNF levels were assessed pre- and post-intervention. Statistical analysis was carried out using the Graph Pad Prism 7.0, and the level of significance was set at 5%. Significant improvements were observed in cognitive test scores, and BDNF levels in MICT and HIIT groups (p < 0.05). There were no significant differences in cognitive function between MICT and HIIT. The present study implicates that 8 weeks of MICT or HIIT may be a very useful non-pharmacological treatment option to improve cognitive function, and BDNF levels in middle-aged overweight men.

Indexed as

High-Intensity Interval TrainingBrain-Derived Neurotrophic FactorCognitionHumansMaleMiddle AgedObesityOverweightBrain-Derived Neurotrophic FactorBrainCognitive functionObesityPhysical activityPhysical exercise

Identifiers

PMID34762211
OpenAlexW3211399768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.