ArticlePlanta2021
Regulation of dhurrin pathway gene expression during Sorghum bicolor development.
Article in Planta, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Multimodal single cell analysis reveals a link between flowering and leaf initiation.bioRxiv : the preprint server for biology · 2026Article
- Nitrogen Status Rewires Transcriptional Regulation of Dhurrin, a Dual-Purpose Defense Metabolite inPlant direct · 2026Article
- Ancient pangenomic origins of noncanonical NLR genes underlying the recent evolutionary rescue of a staple crop.Science advances · 2025Article
- Genotype × Environment Effects in Three Wild Relatives of Sorghum From Australia.Plant-environment interactions (Hoboken, N.J.) · 2025Article
- Saline irrigation improves survival of forage sorghum but limits growth and increases toxicity.Plant biology (Stuttgart, Germany) · 2025Article
- Unveiling the Potential Role of Dhurrin in Sorghum During Infection by the Head Smut PathogenPlants (Basel, Switzerland) · 2025Article
- Dhurrin: a potential endogenous nitrogen turnover source for early seedling growth in sorghum.Frontiers in plant science · 2025Article
- Dhurrin in Sorghum: Biosynthesis, Regulation, Biological Function and Challenges for Animal Production.Plants (Basel, Switzerland) · 2024Review
- Globally deployed sorghum aphid resistance gene RMES1 is vulnerable to biotype shifts but is bolstered by RMES2.The plant genome · 2024Article
- The Putative GATA Transcription FactorLife (Basel, Switzerland) · 2024Article
- Comparative analysis of sorghum (C4) and rice (C3) plant headspace volatiles induced by artificial herbivory.Plant signaling & behavior · 2023Article
- Cyanogenesis in theGenes · 2022Article
- Effects of germination and lactic acid fermentation on nutritional and rheological properties of sorghum: A graphical review.Current research in food science · 2022Review
- Amino acid substrate specificities and tissue expression profiles of the nine CYP79A encoding genes in Sorghum bicolor.Physiologia plantarumArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
MAIN
conclusionDevelopmental and organ-specific expression of genes in dhurrin biosynthesis, bio-activation, and recycling offers dynamic metabolic responses optimizing growth and defence responses in Sorghum. Plant defence models evaluate the costs and benefits of resource investments at different stages in the life cycle. Poor understanding of the molecular regulation of defence deployment and remobilization hampers accuracy of the predictions. Cyanogenic glucosides, such as dhurrin are phytoanticipins that release hydrogen cyanide upon bio-activation. In this study, RNA-seq was used to investigate the expression of genes involved in the biosynthesis, bio-activation and recycling of dhurrin in Sorghum bicolor. Genes involved in dhurrin biosynthesis were highly expressed in all young developing vegetative tissues (leaves, leaf sheath, roots, stems), tiller buds and imbibing seeds and showed gene specific peaks of expression in leaves during diel cycles. Genes involved in dhurrin bio-activation were expressed early in organ development with organ-specific expression patterns. Genes involved in recycling were expressed at similar levels in the different organ during development, although post-floral initiation when nutrients are remobilized for grain filling, expression of GSTL1 decreased > tenfold in leaves and NITB2 increased > tenfold in stems. Results are consistent with the establishment of a pre-emptive defence in young tissues and regulated recycling related to organ senescence and increased demand for nitrogen during grain filling. This detailed characterization of the transcriptional regulation of dhurrin biosynthesis, bioactivation and remobilization genes during organ and plant development will aid elucidation of gene regulatory networks and signalling pathways that modulate gene expression and dhurrin levels. In-depth knowledge of dhurrin metabolism could improve the yield, nitrogen use efficiency and stress resilience of Sorghum.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.